Immunocompromised Fungal Infections

Question 1

Inhibition of RNA/DNA synthesis in nucleus

Answer 1

Flucytosine

Question 2

Inhibition of Egosterol synthesis in cell membrane

Answer 2

Azoles

Fluconazole, Ketoconazole, Itraconazole, Voriconazole, Posaconazole

Question 3

Inhibition of B-1,3-glucan synthesis in cell wall

Answer 3

Echinocandins:

Caspofungin, Micafungin, Anidulafungin

Question 4

Ergosterol disruption in cell membrane

Answer 4

Polyenes:-

Amphotericin B
Abelcet (ABLC)
AmBisome (L-AMB)
Amphotec (ABCD)

Question 5

Polyenes: Amphoterecin B (Fungizone)

Answer 5

1- Given IV

2- Renal toxic —-> Azotaemia

3- Works on Ergestrol

4- Good for Candida albicans and Aspergilles

Question 6

Fluconazole

Answer 6

1- Works on Ergestrol synthesis

2- Inhibits CP450 (liver) —> so worry about metabolism of other drugs patient is taking

Question 7

Voriconazole

Answer 7

1- Visual disturbances

2- Drug of choice for Invasive Aspergilles

Question 8

Flucytosine

Answer 8

1- Inhibits DNA/RNA synthesis

2- Can never be used alone

3- Nephrotoxic

Question 9

Echinocandins: Caspofungin

Answer 9

1- Most common drug now for Candidemia

2- Inhibit B-1,3-glucan synthesis (‘disruption of cell wall’)

3- Only IV (not oral)

Question 10

Aspergillosis

Answer 10

Voriconazole

Question 11

Candidiasis

Answer 11

Caspofungin / Flucanazole

Question 12

Cryptoccocosis

Answer 12

Amphotericin B + Flucytosine

Question 13

Zygomycosis (Mucormycosis)

Answer 13

Amphotericin B

Question 14

Pneumocystitis

Answer 14

Sulfa drugs

Question 15

Histoplasmosis

Answer 15

Amphotericin B / Itraconazole

Question 16

Coccidioidomycosis

Answer 16

Itraconazole

Question 17

Penicillinosis

Answer 17

Itraconazole

Question 18

Sporotrichosis

Answer 18

Potassium Iodide

Question 19

Dermatophytosis

Answer 19

Griseofulvin