Immuno Quiz from teams Flashcards
1
Q
1. Which of the following is an important mediator produced by mast cells and basophils causing vascular dilatation and smooth muscle contraction in the immediate IgE-dependent allergic reaction? Histamine PGD2 Platelet activating factor (PAF) IL-13
A
Histamine
2
Q
2. Which of the following cytokines is critical for the growth and survival of CD3+CD4+CD25 high regulatory T cells? IL-10 IL-2 IL-1 IL-4
A
IL-2
3
Q
- Which of the following statements is consistent with the process of clonal selection?
The specificity of a lymphocyte antigen receptor changes to accommodate the structure of an antigen that binds to it.
Many different antigen receptors with different specificities are expressed on each lymphocyte.
Lymphocytes do not express antigen receptors on their cell surfaces until after exposure to antigen.
The diversity of the lymphocyte repertoire for antigens is very small before exposure to antigen but increases significantly after antigen exposure.
The diversity of the lymphocyte repertoire for antigens is very large before exposure to antigen, with millions of different clones of lymphocytes, each having a different specificity.
A
The diversity of the lymphocyte repertoire for antigens is very large before exposure to antigen, with millions of different clones of lymphocytes, each having a different specificity.
4
Q
4. In naive T cell recirculation, entry of the cells into peripheral lymph nodes occurs through which specialized vessel? Efferent lymphatic Thoracic duct Central artery High endothelial venule Sinusoid
A
High endothelial venule
5
Q
5. Which one of the following are neutrophils attracted/recruited to by an infected area? IgM Complement C1 Complement C5a Complement C8 Complement C3b
A
Complement C5a
6
Q
- Which of the following do patients with severely reduced Complement C3 levels tend to have?
Increased numbers of viral infections
Increased numbers of bacterial infections
Low gamma globulin levels
Frequent episodes of hemolytic anemia
Increased occurrence of lupus erythematosus
A
Increased numbers of bacterial infections
7
Q
7. Antigen-presenting cells that activate helper T cells must express which one of the following on their surfaces? IgE Gamma interferon Class I MHC antigens Class II MHC antigens Complement CR2
A
Class II MHC antigens
8
Q
8. Which one of the following produces superoxide anion (O2-) in respiratory burst? NADPH oxidase FAD reductase lysozyme superoxide dismutase myeloperoxidase
A
NADPH oxidase
9
Q
9. The most common co-stimulatory interaction for T cell activation involves CD28 on the naive T cell binding to the\_\_\_\_\_\_\_\_\_ on the antigen-presenting cell (APC): CD4 mofule B7 molecule IgD splicing mechanism CD40 CD40 ligand
A
B7 molecule
10
Q
- The most common defect in chronic granulomatous disease (CGD) is attributed to:
chemotactic machinery in neutrophils is disabled
defective cell adhesion molecules in endothelium
NADPH oxidase deficiency in phagocytic cells
neutrophil are arrested in development at myelocyte stage
T-helper lymphocytes are incompetent
A
NADPH oxidase deficiency in phagocytic cells
11
Q
- Which of the following is least likely to be considered a part of innate immunity?
antibody production by plasma cells
chemical agents from various body secretions
neutrophils and natural killer cells
Toll-like receptor on phagocytic cells
respiratory tract being coated with mucus
A
antibody production by plasma cells
12
Q
12. Which of the following substances is NOT a cell-derived component of vascular edema? histamine perforin platelet activator factor (PAF) prostacyclin prostaglandin
A
perforin
13
Q
13. Neurtrophils and eosinophils develop in which primary lymphoid organ? Bone marrow Lymph nodes Spleen Thymus
A
Bone marrow
14
Q
14. The\_\_\_\_\_\_\_cell is the mature B lymphocyte able to respond to antigen in secondary lymphoid tissues? IgD+ IgG+ IgM+ IgM+IgD+ IgM+IgG+
A
IgM+IgD+
15
Q
- A cytokine with paracrine activity acts upon:
An adjacent cell from the cell of origin
The same cell which secreted the molecule
An interferon-gamma secreting cell
Cells in a different vascular-tissue location
Progenitor stem cells
A
An adjacent cell from the cell of origin
16
Q
16. Which of the following cells is part of the adaptive immune system? Basophils Eosinophils Fibroblasts Neutrophils Plasma cells
A
Plasma cells
17
Q
17. Macrophages were once what type of peripheral blood cell? Basophil Eosinophil Monocyte Neutrophil Platelet
A
Monocyte
18
Q
18. The mechanism of the adaptive immune system in humans to directly eliminate virally infected cells involves which cell type CD4+ Th1 cells CD4+ Th17 cells CD8+ T cells Macrophages Plasma cells
A
CD8+ T cells
19
Q
- Which of the following is NOT considered a primary purpose of inflammation?
generate inflammatory mediators to sustain response
localization to eliminate cause of pathogenic insult
promote and sustain tissue injury/destruction
reaction of living tissue in response to injury
restore normal physiology
A
promote and sustain tissue injury/destruction
20
Q
- Which of the following pairs is mismatched?
T-cell activation: cell division and differentiation
effector B cell: plasma cell
plasma cell: antibody secretion
natural T cell: kills parasite
helper T cell: facilitates B cell differentiation
A
natural T cell: kills parasite
21
Q
- Which of the following pairs is mismatched?
plasma cell: phagocytic and killing of microorganisms
dendritic cell: activation of adaptive immune responses
natural killer cell: develops from lymphoid stem cell
neutrophil: formation of pus
regulatory T cell: inhibition of T cell effector activity
A
plasma cell: phagocytic and killing of microorganisms
22
Q
- What are the consequences of CD40L expressed on an antigen-stimulated T cell binding to CD40 on an APC?
Increased CD4-T cell binding to MHC II-peptide
Increased expression of B7 co-stimulators
Increased T cell CD3 signaling of T cell receptor
Increased expression of constitutive TLR’s on APC
A
Increased expression of B7 co-stimulators
23
Q
- Affinity maturation occurs in the _____________of lymph nodes and is the result of _______________ of Ig genes in dividing B cells, respectively:
Paracortex and switch recombination
Medulla and RAG-1/-2 recombination
White pulp and homologous recombination
Germinal center and somatic hypermutation
A
Germinal center and somatic hypermutation
24
Q
24. Lymphocyte markers often test for CD3, CD4, CD8, CD19, and CD16/56 cells. CD16/56 cells are which one of the following? B cells T helper cells Total T cells Cytotoxic T cells NK cells
A
NK cells
