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FA - Immunology > Immuno - Immunosuppressants (Recombinant cytokines & Therapeutic antibodies) > Flashcards

Immuno - Immunosuppressants (Recombinant cytokines & Therapeutic antibodies) Flashcards

Pg. 216-217 in First Aid 2014 Sections include: -Recombinant cytokines and clinical uses -Therapeutic antibodies

1
Q

Name 9 recombinant cytokines.

A

(1) Epoeitin alfa (erythropoietin) (2) Thrombopoietin (3) Oprelvekin (IL-11) (4) Filgrastim (GCSF) (5) Sargramostim (GMCSF) (6) Aldesleukin (IL-2) (7) IFN-alpha (8) IFN-beta (9) IFN-gamma

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2
Q

What is the name of the recombinant agent for erythropoietin? What is its clinical use, and especially in what context?

A

Epoetin alfa (erythropoietin); Anemias (especially in renal failure)

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3
Q

What is the clinical use of (recombinant) thrombopoietin?

A

Thrombopoietin; Thrombocytopenia

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4
Q

What is the name of the recombinant agent for interleukin-11? What is its clinical use?

A

Oprelvekin (interleukin-11); Thrombocytopenia

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5
Q

What is the name of the recombinant agent for granulocyte colony-stimulating factor? What is its clinical use?

A

Filgrastim (granulocyte colony-stimulating factor); Recovery of bone marrow

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6
Q

What is the name of the recombinant agent for granulocyte-macrophage colony-stimulating factor? What is its clinical use?

A

Sargramostim (granulocyte-macrophage colony-stimulating factor); Recovery of bone marrow

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7
Q

What is the name of the recombinant agent for interleukin-2? What are 2 of its clinical uses?

A

Aldesleukin (interleukin-2); Renal cell carcinoma, metastatic melanoma

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8
Q

What are 6 clinical uses of (recombinant) IFN-alpha?

A

(1) Chronic hepatitis B and C (2) Kaposi sarcoma (3) Hairy cell leukemia (4) Condyloma acuminatum (5) Renal cell carcinoma (6) Malignant melanoma

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9
Q

What is the clinical use of (recombinant) IFN-beta?

A

Multiple sclerosis

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10
Q

What is the clinical use of (recombinant) IFN-gamma?

A

Chronic granulomatous disease

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11
Q

What are 5 therapeutic antibodies used as cancer therapy?

A

(1) Alemtuzumab (2) Bevacizumab (3) Cetuximab (4) Rituximab (5) Trastuzumab

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12
Q

What is the target of Alemtuzumab? What is its clinical use?

A

CD52; CLL; Think: “aLYMtuzumab - chronic LYMphocytic leukemia”

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13
Q

What is the target of Bevacizumab? What are 2 of its clinical uses?

A

VEGF; (1) Colorectal cancer (2) Renal cell carcinoma

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14
Q

What is the target of Cetuximab? What are 2 of its clinical uses?

A

EGFR; (1) Stage IV colorectal cancer (2) Head and neck cancer

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15
Q

What is the target of Rituximab? What are 3 of its clinical uses?

A

CD20; (1) B-cell non-Hodgkin lymphoma (2) Rheumatoid arthritis (with MTX) (3) ITP

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16
Q

With what is Rituximab used to treat Rheumatoid arthritis?

A

Rheumatoid arthritis (with MTX)

17
Q

What is the target of Trastuzumab? What are 2 of its clinical uses?

A

HER2/neu; Think: “HER2 - tras2zumab”; (1) Breast cancer (2) Gastric cancer

18
Q

What are 3 therapeutic antibodies used for autoimmune disease therapy?

A

(1) Infliximab (2) Adalimumab (3) Natalizumab

19
Q

What is the target of Infliximab? What other therapeutic antibody has this target?

A

TNF-alpha; Adalimumab

20
Q

What are 2 therapeutic antibodies that target TNF-alpha? What are 4 clinical uses for them?

A

Infliximab, Adalimumab; Think: “Rheumatoid arthritis ‘INFLIX’ pain in ‘DA LIMbs’”; (1) IBD (2) Rheumatoid arthritis (3) Ankylosing spondylitis (4) Psoriasis

21
Q

What is the target of Natalizumab? What is this target’s function?

A

Alpha4-integrin: leukocyte adhesion

22
Q

What are 2 clinical uses for Natalizumab?

A

(1) Multiple sclerosis (2) Crohn disease

23
Q

What risk is associated with Natalizumab, and in what patient population?

A

Risk of PML in patients with JC virus

24
Q

What is the target of Abciximab? What is its clinical use?

A

Glycoprotein IIb/IIIa; Think: “IIb times IIIa equals ‘abSIXimab’”; Anti-platelet agent for prevention of ischemic complications in patients undergoing percutaneous coronary intervention

25
Q

What is the target of Denosumab? What is its clinical use? How does Denosumab work, and what substance does it mimic?

A

RANKL; Osteoporosis; Inhibits osteoclast maturation (mimics osteoprotegrin); Think: “denOSumab affect OSteoclasts”

26
Q

What is the target of Digoxin immune Fab? What is its clinical use?

A

Digoxin; Antidote for digoxin toxicity

27
Q

What is the target for Omalizumab? What is its clinical use? How does this work?

A

IgE; Allergic asthma; Prevents IgE bindings to Fc(Epsilon)RI

28
Q

What is the target for Palivizumab? What is its clinical use?

A

RSV F protein; RSV prophylaxis for high-risk infants; Think: “paliVIzumab - VIrus”

FA - Immunology (14 decks)

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