Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Path > Immuno > Flashcards

Immuno Flashcards

1
Q

Bare lymphocyte syndrome (2 types)

A

T1= absent MHC 1
T2= Absent MHC2
Assoc w/ sclerosing cholangitis, hepatomemegaly + jaundice by 3months

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

DiGeorge

A

CATCH22 - 22q11

Normal B cells + IgM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Kostamnn

A

Severe congenital neutropoenia

NBT +ve

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

LAD

A

Neutrophilia + NBT+ve

Delayed cord separation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Cyclical neutropoenia

A 
Neutropoenia for 6 days every 3 week
Aut dom (ELA2 mut)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

CGD

A

NBT -ve, NADPH oxidase def

X linked

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Wiskott-Aldrich

A

Mut in WASp
Low IgM, w/ High IgA+G
Epistaxis + eczema
X linked

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Reticular dysgenesis

A

Absolute def in granulocytes + lymphos

Severe neonatal sepsis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Chediak Higashi

A

Protein trafficking defect (microtubules)

Neutropoenia, defective 1o haemostasis+ albinism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Complement deficiencies (classical)

A

CH50 test abnormal

Assoc w/ SLE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Complement deficiencies (alt)

A

AP50 test abnormal

Predisposes to infection w/ encapsulated bacteria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Complement deficiencies (common)

A

Both AP50 and CH50 tests abnormal

assoc w/ MPGN

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Hereditary angioedema

A

C1 inhibitor deficiency

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

POEMS

A

Polyneuropathy, Papilloedema, Pulmonary disease
Organomegaly, Oedema
Endocrinopathy
M protein
Skin abnormalities (hyerpig + hypertrich)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

HLA DQ2

A

Coeliac (two eight or not to eat?)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

HLA B27

A

Ank spond

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

HLA DR2

A

Goodpasture’s (DR15)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

HLA DR3

A

SLE, Grave’s, MG + T1DM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

HLA DR4

A

RA + T1DM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

PTPN22

A

RA, SLE + T1DM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

CTLA4

A

SLE, T1DM, Grave’s

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Anti Rh blood group Ag Ab

A

AIHA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Anti RBC Ag Ab

A

AIHA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Anti GlpIIa/IIIb

A

ITP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

pANCA

A

Churg Strauss (eMPA), MPA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Anti GBM (T4 collagen)

A

Goodpasture’s (T1 RPGN)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

Anti gastric parietal cell + Anti IF

A

Pernicious Anaemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

cANCA

A

Wegener’s (T3 RPGN)

29
Q

Anti TSH R Ab (stim)

A

Grave’s

30
Q

Anti AChR Ab

A

MG

31
Q

Anti dsDNA

A

SLE

32
Q

Anti histone

A

Drug induced SLE

33
Q

ANA

A

SLE, Sjorgren’s, AI hep + dermatopolymyosistis

34
Q

Anti Ro

A

SLE, Sjorgren’s, Congenital heart block

35
Q

Anti La

A

SLE, Sjorgren’s (speckled on IF)

36
Q

Anti U1RNP

A

SLE, Mixed CTD

37
Q

Anti Jo1 (+RNA Synthetase)

A

Dermatomyositis/Polymyositis

38
Q

Anti CCP

A

RA

39
Q

Anti GAD

A

T1DM

40
Q

Anti IA2 + phogrin

A

T1DM (tyrosine phosphatases)

41
Q

Anti Mitochondrial

A

Primary Biliary Cirrhosis

42
Q

Anti Centromere

A

Limited Cutaneous Scleroderma (CREST)

43
Q

Anti topoisomerase/Scl70 + RNA pol 1,2+3 + Fibrillarin

A

Diffuse Cutaneous Scleroderma

44
Q

Anti Thyroglobulin, Thyroperoxidase

A

Hashimoto’s thyroiditis

45
Q

Anti EMA

A

Coeliac (cause of dermatitis herpetiformis)

46
Q

Anti robinucleoprotein

A

Mixed CTD (=Anti URNP1!)

47
Q

Anti Cardiolipin + B2 glp

A

Antiphospolipid

48
Q

ANA + SMA

A

T1 AI Hep

49
Q

Anti LKM 1 Ab

A

T2 AI Hep

50
Q

Anti Soluble liver AB

A

T3 AI Hep

51
Q

Antiganglioside GM

A

ALS

52
Q

Antiganglioside LM

A

Guillain Barre

53
Q

RPGN Types

A

T1= Anti GBM= Goodpasture’s w/ linear stain
T2= Immune complex= IgA neph w/ granular stain
T3= Pauci-immune= Wegener’s/MPA w/ absent stain
NB all cause Crescent formation

54
Q

Muromonab (OKT3)

A

Anti CD3

55
Q

Basilixumab

A

Anti IL2R

56
Q

Tocilizumab

A

Anti IL6R

57
Q

Natalizumab

A

Anti aplha4 integrin

58
Q

Daclizumab

A

Anti IL2R

59
Q

Alemtuzumab

A

Anti CD52

60
Q

Abtacept

A

CTLA4-IG fusion protein blocks costume of T cells

61
Q

Efalizumab

A

Anti CD11a

62
Q

Ustekinumab

A

Anti p40 subunit of IL12+23

63
Q

Rituximab

A

Anti CD20

64
Q

Infliximab

A

Anti TNF alpha

65
Q

Etanercept

A

Anti TNF alpha (TNF2R+ IgG1 fusion protein)

66
Q

Denosumab

A

Anti RANKL in bones

67
Q

Anti Lymphocyte globulin

A

Tx allograft rejection

68
Q

Adalimumab

A

Anti TNFalpha - fully humanised

Path (5 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions