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Path > Haem > Flashcards

Haem Flashcards

1
Q

Howell-Jolly Body

A

Hyposplenism

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2
Q

Burr cells

A

Uraemia

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3
Q

Heinz bodies

A

G6PD

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4
Q

Pelger Huet cells (hyposeg neuts)

A

Myelodysplasia

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5
Q

Hypersegmented neuts (Right shift)

A

Megaloblastic anaemia

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6
Q

Schistocytes

A

MAHA

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7
Q

Target cells (codocytes)

A

Hyposplenism, Fe def, Haemoglobinopathies

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8
Q

Tear drop cell (Dactrocyte)

A

Myelofibrosis + dry or bloody BM tap

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9
Q

Atypical Lymphocyte

A

EBV (infectious mononucleosis)

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10
Q

Cabot rings

A

Megaloblastic anaemia

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11
Q

Golf ball cells

A

HbH disease (1 working Hb alpha gene)

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12
Q

APTT

A

Intrinsic pathway (Heparin)

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13
Q

PT

A

Extrinsic pathway (Warfarin)

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14
Q

Haemophilia A

A

FVIII def

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15
Q

Haemophilia B

A

FIX def

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16
Q

vWF clotting screen

A

N PT, Increased APTT, Increased Bleeding time, Decreased Ristocetin activity

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17
Q

Pappenheimer bodies

A

Lead poisoning, Sideroblastic anaemia

18
Q

Glanzmann’s thrombasthenia

A

Mut in GlpIIa/IIIb

19
Q

Bernard-Soulier

A

Mut in GlpIb

20
Q

CML

A

BCR-Abl t(9:22)

21
Q

AML

A

Auer rods, t(15:17), Sudan Black B +ve

22
Q

CLL

A

Smudge cells

23
Q

Hairy cell leukaemia

A

TARP

24
Q

Adult T cell Lymphoma

A

HTLV1, Cloverleaf nuclei

25
Q

ALL

A

Sudan Black B -ve

26
Q

Acute promyelocytic leukaemia

A

CH14 inversion (q11:q32)

27
Q

Protein S deficiency

A

VTE due to persistence of FVa+VIIIa

28
Q

Large granular lyphocytic leukaemia

A

Azurophilic granules in cytoplasm

29
Q

Burkitt’s lymphoma

A

Starry sky t(8:14)

30
Q

Hodgkin’s lymphoma

A

Reed-Sternberg cells

31
Q

Mantle cell lymphoma

A

t(11:14)

32
Q

Follicular lymphoma

A

t(14:18)

Centrocytes, centroblasts

33
Q

Essential thrombocythaemia

A

Erythromyalgia (burning sensation, erythema, swelling)

Hypercellular BM w/ giant plt + megakaryocytes

34
Q

Donath Landsteiner Abs

A

Paroxysmal Cold Haemoglobinuria

35
Q

PNH Feats

A

Pancytopoenia
New thrombus
Haemolysis
Ham’s test

36
Q

MM diagnostic criteria

A

CRAB Sx +
Paraproteinaemia >30g/L OR
Clonal plasma cells >10% BM

37
Q

Smouldering myeloma

A

Serum paraprotein >30g/L or
Clonal plasma cells >10% BM +
NO CRAB

38
Q

MGUS

A

Serum paraprotein less than 30g/L +
Clonal Plasma cells less than 10% +
No CRAB

39
Q

TTP feat

A 
MARCH w/ low platelets
MAHA
A fever
Renal failure
CNS signs (fluctuating)
Haematuria/proteinuria
40
Q

Hypocellular BM

A

Aplastic Anaemia

41
Q

Test for Sickle cell

A

Sodium Metabisulphite

42
Q

Causes of cold AIHA

A

COLD LID
Lymphoproliferative disorders (CLL, Lymphoma)
Infection (Mycoplasma, EBV)
Do not Know

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