Immunity - M

Question 1

IgA

Answer 1

• prevents bacteria and viruses attaching to and penetrating epithelial cells (mucous membranes - constitutive barriers to infection)

found in various secretions, such as saliva, tears, breast milk, mucus, and intestinal fluids. It is the predominant antibody in these secretions, providing a first line of immune defense at mucosal surfaces.

neutralizes toxins + pathogens: prevents the attachment and invasion of pathogens (such as bacteria, viruses, and toxins) to the epithelial cells by binding to them. This prevents the pathogens from penetrating the mucosal barriers and causing infections.

FRONTLINE DEFENSE, does not induce inflammation
- protecting against GI, respiraotry, UGT infections

Question 2

Opsonins - examples

Answer 2

C3b
CRP - C-reactive protein
IgG/IgM Antibodies

Question 3

IgG

Answer 3

• example of opsonin

Question 4

IgM

Answer 4

• example of opsonin

Question 5

production of pro-inflammatory mediators from EARLY INNATE IMMUNE RESPONSE

for localised, acute inflammation

examples

• Macrophages
• Mast cells

Answer 5

NO
Prostaglandins/Leukotrienes
Histamines
Pro-inflammatory cytokines (e.g. TNFa)

Question 6

degranulation

Answer 6

release of pre-foremd pro-inflammatory substances

Question 7

NETs
Neutrophil extracellular traps

Answer 7

Vomatosis - netosis
form of cell death, vomiting out contents of cells

sticky net

PUS