Immunity Flashcards

Innate Immunity

Adaptive Immunity

Properties of Innate Immunity

Antigens

Autoantigen

•Exogenous antigen

•Endogenous antigen

Exogenous Antigen

Endogenous Antigen

Autoantigen

Normal Microbiota
Innate immune system

•Microbial Antagonism (Innate Immunity)

Mechanical Barriers

•Skin (intact) and Epithelium (Type of mechanical barrier)

Ciliated Epithelium and Peristalsis (pushes things out)
Type of mechanical barrier

•Hair (type of mechanical barrier)

Blinking (Mechanical Barrier)
An enzyme that:

•Lysozyme (Chemical Barrier)

Lactoferrin (Chemical Barrier)

•Antimicrobial peptides (chemical barriers)

•Complement (chemical barriers)
Type of protein
What are the two functions of complement (type of protein)?
- Opsonization
- Membrane attack complex
Part of Complement (type of protein) that:

•Opsonization
Part of Complement (type of protein) that:

•Membrane attack complex

Cell with membrane attackers (complement proteins are forming the holes)

Cellular Barriers (innate immunity)

Cellular Barriers (innate immune system)
Process of the innate immune system which:

Phagocytosis (cell grabs pathogen, digests it, and expels it out)



Opsonizatoin (innate immune system)
What are some cellular barriers of the innate immune system that consists of non-phagocytic killing?


•Eosinophils
Part of the innate immune system’s chemical barriers.

Neutrophils
(phagocytosis and digest pathogens)



Herd Immunity
Pros of Subunit vaccines
–No exposure to pathogen
Cons of Subunit vaccines
–Expense - may be produced in recombinant organisms
–Immune response less than attenuated or inactivated
Type of vaccine that:

Subunit vaccines
Pros of Toxoid vaccines
–Useful for organisms that cause illness due to toxin
–Do not have to be exposed to cells of pathogen
Cons of Toxoid vaccines
–Boosters
Type of vaccine that:

Toxoid vaccines
Cons of Inactivated (killed) vaccines
–Immune response not as strong as attenuated vaccines
–Requires boosters
Pros of Inactivated (killed) vaccines
–More stable than attenuated vaccines
–Microbiologically safer than attenuated
Type of vaccine that:

Inactivated (killed) vaccines
Pros of Attenuated (live) vaccines
–Produce a strong immune response (B and T cell)
–Contact Immunity
Cons of Attenuated (live) vaccines
–Need to remain refrigerated
–Mild signs and symptoms
–Possibility of reversion and disease causation
Type of vaccine that:

Attenuated (live) vaccines
Types of Vaccines
- Attenuated vaccines
- Inactivated vaccines
- Toxoid vaccines
- Subunit vaccines

Vaccination

Passive Immunity
Type of passive immunity that is:
•Mother to offspring (colostrum)
–Natural Passive
Type of passive immunity that is:
•Individual receives pre-formed antibodies via injection
–Artificial Passive
•Individual produces antibodies in response to presence of antigen
Active Immunity
Type of active immunity that:
•Exposure to antigen in day to day life
–Natural Active
Type of active immunity that:
•Response to antigens introduced via a vaccine
–Artificial active
•Process by which memory B cells (and T cells) are produced
Immunization
Types of Immunizations:
–Active
–Passive
–Natural
–Artificial

Primary response (green)
Secondary response (orange)
Type of B lymphocytes

•B Memory Cells
Type of B lymphocyte

•B Plasma Cells
Type of T lymphocytes

•Cytotoxic T cells (Tc)
Type of T Lymphocytes

•T helper cells (Th)
•Antibodies function in several ways by:
–Complement activation
–Opsonization
–Neutralization
–Agglutination
–Complement activation
–Opsonization
–Neutralization
–Agglutination
Antibody function

–Neutralization
(Antibody function)

–Agglutination (antibody function)

–Opsonization (antibody function)

Antibodies

Antibody structure

Antibodies

Influenza Antigens and Epitopes

O and H antigens
Bacterial Serotypes and Epitopes

Antigens

•Epitope (antigenic determinant)

Microbial Antigens

Adaptive (Acquired) Immunity

Fever (Innate Immunity)

Fever (Innate Immunity)

Fever (Innate Immunity)

•Natural Killer (NK) cells
Cellular Defenses (Innate)

Non-Antigen Pathogen Recognition
(Innate Immunity)
•TLRs

Non-Antigen Pathogen Recognition
(Innate Immunity)
•PAMPs
Apoptosis
Programmed Cell Death

•Neutrophil Extracellular Traps (NETs)
Pukes out DNA and contents to kill pathogen