Immunity Flashcards

1
Q

Involves production of antibodies and generation of specialized lymphocytes against specific antigens

A

Immune response

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2
Q

Molecules from a pathogen or foreign organism that provokes a specific immune response molecular weight of >10,000

A

ANTIGEN

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3
Q

Small foreign molecule that is not antigenic

Must be coupled to a carrier molecule to be antigenic

Once antibodies are formed they will recognize hapten

A

HAPTEN

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4
Q

A critical aspect of an effective immune response is the ability to avoid unleashing its destructive mechanisms against the host’s own tissues

A

DISCRIMINATION OF β€œself vs nonself”

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5
Q

Avoidance of othe destruction of self-tissues

Failure of self-tolerance results in autoimmune diseases

A

Self-tolerance

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6
Q

The ability of the body to fight infection and/or foreign invades that tend to damage the tissues and organs by producing antibodies or killijg infected cell

A

IMMUNITY

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7
Q

Anaphylactic type

A

Type 1

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8
Q

Immediate hypersensitivity

A

Type 1

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9
Q

Reaction within minutes

May be systemic or localized

A

TYPE 1 (ANAPHYLACTIC TYPE; IMMEDIATE HYPERSENSITIVITY)

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10
Q

Ag binds to IgE on surface of sensitized mast cell and basophils

A

TYPE 1 (ANAPHYLACTIC TYPE; IMMEDIATE HYPERSENSITIVITY)

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11
Q

Present before birth

β€œNatural”

A

INNATE

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12
Q

Developed by exposure to pathogens or in a broader sense, antigens not recognized by the MHC

A

ADAPTIVE

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13
Q

A set of molecules displayed om cell surfaces that are responsible for lymphocyte recognition and β€œantigen presentation”

The MHC molecules control the immune response through recognition of β€œself” and β€œnonself” and severe as targets in transplantation rejection

A

MAJOR HISTOCOMPATIBILITY COMPLEX

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14
Q

Composed of two polypeptide chains

About 350 amino acids long

Glycosylated

Total molecular weight of about 45kDa

A

CLASS I MHC

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15
Q

Composed of two polypeptide chains

About 230 and 240 amino acids long

Glycosylated

Molecular weights of about 33 kDa and 28 kDa

A

CLASS II MHC

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16
Q

Anatomy of a lymph node

A

Naive lymphocytes circulate between blood and lymphoid tissues; antigen in tissue arrives at draining lymph node via lymph flow and being carried by dendritic cells

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17
Q

Proteins that recognize and bind to a particular antigen with very high SPECIFICITY

A

ANTIBODIES

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18
Q

One virus or microbe may have several antigenic determinant sites, to which different antibodies may bind

A

ANTIBODIES

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19
Q

Belong to a group of serum proteins called IMMUNOGLOBULINS (Igs)

A

ANTIBODIES

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20
Q

Primary immune response

A

IgG

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21
Q

Crosses the placenta

A

IgG

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22
Q

Most versatile immunoglobulin

A

IgG

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23
Q

Major Ig in serum 75%

A

IgG

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24
Q

Only class of Ig that crosses the placenta

A

IgG

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25
Q

Opsonizes bacteria for phagocytosis

A

IgG

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26
Q

FIXES COMPLEMENT enhancing bacterial killing, secondary responses

A

IgG

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27
Q

NEUTRALIZES bacteial toxins and viruses

A

IgG

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28
Q

Found on mucosal surfaces

Secretions (saliva, sweat, tears)

A

IgA

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29
Q

Second most common serum Ig

A

IgA

30
Q

Secretory

Prevents attachment of bacterial and viruses to mucous membranes

Does not fix complement

Major antibody of milk, colostrum, saliva, semen

A

IgA

31
Q

PENTAMER

A

IgM

32
Q

Does not cross the placenta barrier

A

IgM

33
Q

The first Ig to be made by the fetus and the first Ig to be made by a naive B cells

A

IgM

34
Q

Produced before other Ig

A

IgM

35
Q

Produd in primary response

Fixes complement

Does not cross placenta

Antigeni receptor on surface of B cells

A

IgM

36
Q

Mediates immediate hypersensitivity by releasing mediators from mast cells and basophils

A

IgE

37
Q

Defends against parasitic/helminthic infections by releasing enzymes from eosinophils

A

IgE

38
Q

Does not fix complement

A

IgE

39
Q

Least common Ig

A

IgE

40
Q

Least common serum Ig since it binds very tightly to Fc receptors on basophils and mast cells even before interacting with antigen

A

IgE

41
Q

Uncertain

Found on surface of most B cells and in serum

Important in B cell activation

Functions as antigen receptors

A

IgD

42
Q

Amino terminus

A

VARIABLE REGION

43
Q

Carboxyterminus

A

CONSTANT REGION

44
Q

C3a

A

Anaphylatoxins

45
Q

C3b

A

Opsonization

46
Q

Two mechanisms of complement dependent

A

Dirct lysis by complement activation

Lysis by opsonization

47
Q

Hypersensitivity reaction characterized by production of an IgG or IgM or antibody directed against a specific target cell or tissue

A

Type II HYPERSENSITIVITY (CYTOTOXIC TYPE)

48
Q

Monocytes, neutrophils, eosinophils or NK cell recognized cells by Fc portion of IgG bound to cell and kill cell without phagocytosis

A

Ab-dependent cell mediated cytotoxicity

49
Q

Good pasture’s syndrome

A

Ab-dependent cell mediated cytotoxicity

50
Q

Non-cytotoxic

A

Anti-receptor antibodies

51
Q

Myasthenia gravis

A

Anti-receptor antibodies

52
Q
  1. Transfusion reactions
  2. Hemolytic disease of the newborn (ERYTHROBLASTOSIS FETALIS)
  3. Autoimmune hemolytic anemia, agranulocytosis and thrombocytopenia
A

ANTIBODY-MEDIATED (TYPE II)

53
Q

Antibody-mediated (type II)

A

Autoimmune hemolytic anemia

Autoimmune thrombocytopenic purpura

Pemphigus vulgaris

Vasculitis caused by ANCA

Goodpastures syndome

Acute rheumatic fever

Myasthenia gravis

Graves disease (hyperthyroidism)

Insulin-resistant diabetes

Pernicious anemia

54
Q

Antigen-Antibody complexes produce tissue damage

A

Type III IMMUNE COMPLEX MEDIATED

55
Q

Sequela to the administration of large amound of foreign serum

A

ACUTE SERUM SICKNESS

56
Q

Localized area of tissue necrosis resulting from acute immune complex vasculitis, usually elicited in the skin

A

LOCALIZED FORM (ARTHUS REACTION)

57
Q

Lesion develops over 4-10 hours may ulcerate

A

LOCALIZED FORM (ARTHUS REACTION)

58
Q

Histo shows fibrinoid necrosis of vessels, platelet thrombosis, edema, hemorrhage, and numerous neutrophils

A

LOCALIZED FORM (ARTHUS REACTION)

59
Q

Immune complex mediated (type III)

A

SLE

PSGN

POLYARTHRITIS NODOSA

SERUM SICKNESS

ARTHUS REACTION

60
Q

Mediated by sensitized cells

A

TYPE IV (CELL MEDIATED)

61
Q

X-Linked Agammaglobulinemia (Bruton’s Agammaglobulinemia)

Common Variable Immunodeficiency

Isolated IgA Deficiency

Hyper-IgM Syndrome

DiGeorge Syndrome (Thymic Hypoplasia)

Severe Combined Immunodeficiency

Immunodeficiency with Thrombocytopenia and Eczema (Wiskott-Aldrich Syndrome)

A

Primary Immunodeficiency

62
Q

Immunodeficiency with thrombocytopenia and eczema

A

Wiskott-Aldrich Syndrome

63
Q

Ensures that distinct microbes elicit specific responses

A

SPECIFICITY

64
Q

Enables immune system to respond to large variety of microbes

A

DIVERSITY

65
Q

Leads to enhanced responses to repeated exposures to the same microbe

A

MEMORY

66
Q

Generates responses that are optimal for defense against different types of microbes

A

SPECIALIZATION

67
Q

Allows immune system to respond to newly encountered microbes

A

SELF-LIMITATION

68
Q

Prevents injury to the host during responses to microbes

A

NONREACTIVITY TO SELF

69
Q

Due to (-) or low adherence glycoprotein receptors on leukocytes –> impaired leukocyte invasion

A

LEUKOCYTE ADHESION DEFICIENCY

70
Q

Delayed separation of umbilical cord impaired wound healing, decreased pus formation, gingivitis, cellulitis, necrotic abscess

A

LEUKOCYTE ADHESION DEFICIENCY

71
Q

Persistent neutrophilia

Rebucj skin window test

A

LEUKOCYTE ADHESION DEFICIENCY

72
Q

Diagnosis can often be made in infancy with the onset of a distinct neonatal rash

Furunculosis, staphylococcal pneumonias, candidiasis are typical presentations

Allergy and parasitism

Eosinophilia is a consistent findinf

Total serum IgE concentrations higher than 2000 IU/ml

The defect of neutrophil chemotaxis

A

HYPER-IgE SYNDROME or JOBS SYNDROME