Immunity

Question 1

Seasonal, cat-related asthma & urticaria

Nasal mucosal polyp

Answer 1

IgE— mast cell -> degranulation histamine -> vasodilation, increased vascular permeability, bronchial smooth muscle contraction, mucous gland secretion

Question 2

M weakness, inc ptosis, diplopia

Chest-> mediastinal mass is found

Answer 2

Myasthenia gravis -> hyperplasia

Type 2-Ach receptor antibodies block neuromuscular junction Ach receptors

Question 3

M weakness, acute res distress,

Answer 3

Thymoma, -> seen in myasthenia gravis

Paraneoplastic syndrome of this-> lambert-eaton myasthenia syndrome w small cell cancer

Question 4

Skin rash w raised scaly erythema in sun-exposed areas

Answer 4

Discoid lupus erythematosus

Type 3-antibody & antigen complexes

Question 5

Applied deodorant-> 30 h later, rash shown

Answer 5

Contact dermatitis-> type4 (delayed)
Eg) poison ivy
Cutaneous macropgages & dendritic cells take up ptoteins-> CD4 T recognize-> Th 1 (by interferon gamma)

Diabetes mellifluous s, scleroderma, infl bowel ds,

Question 6

BCG-> TB skin test

Answer 6

Memory T cells recognize BCG

CD 4 cells elaborate interferon-gamma-> activates macrophage, which elaborate IL-12

Activated T cells produce IL-2-> T cell proliferation

Question 7

Acute myelogenous leukemia-> allogeneic bone marrow stem cell transplantation w 6 HLA antigen match

6m later) jaundice, watery diarrhea, scaling rash

Answer 7

Graft versus host disease

Apoptosis & dermal fibrosis

Question 8

Recurrent respiratory, urinary tract infections
Cytomegalovirus & adenovirus cultured from her lungs
Bronchoalveolar lavage-> shown organisms by silver staining

Answer 8

Pneumocystis jiroveci(cup shaped)

Question 9

Hay fever, difficulty breathing

Nasal blockage

Answer 9

Type 1 hypersensitivity -> IgE

Th2 type helper — IL 4–>B cell -> Ig E (class switching)