Bone

Question 1

Introduction to bone mineral homeostasis
–

Answer 1

Osteoclasts:
Responsible for ______________ of bone matrix

Osteoblasts:
——-protein matrix and control mineralization

Osteocytes:
Buried in newly formed bone and connect with one another to form a system which controls the rate of ion transport and regulates the rate of mineralization in new bone matrix

Question 2

Bone Composition

Answer 2

Two major mineral constituents
– 1.
-2.

Question 3

Calcium disposition in body

Answer 3

Very small amount of calcium exists in the free or active form

% exists in crystalline form in your skeleton and teeth

% exists in 2 main compartments

• 0.9% intracellularly within the soft tissue
• 0.1% extracellularly
• complexed w phosphates, citrate

Question 4

Introduction to bone mineral homeostasis
Definitions
Homeostasis:

Answer 4

adjustments required to maintain constant free calcium concentrations on a minute to minute basis

• Balance:
  adjustments to maintain a constant amount of total calcium concentration within the body