Immunfarmakologi Flashcards

1
Q

Pro-inflmmatoriske Cytokiner

A
  • IL-1

- TNF-alpha

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2
Q

Anti-inflmmatoriske Cytokiner

A
  • IL4
  • IL10
  • Il13
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3
Q

Virkning:

DMARDs

A

Diesease modifying anti-rheumatic drugs:
Reducerer sygdomsaktivitet
- færre ømme led
- mindre smerte
- bedre mobilitet
(Langsom effekt, derfor kombi med NSAIDs)

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4
Q

Virker på:

Glukokortikoider

A
  • smertestillende
  • immunsuppressive (holder nede - over lang tids brug)
  • anti-inflammatorisk
    • hæmmer COX
    • hæmmer precurser for cytokiner
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5
Q

Bivirkninger:

NSAID

A
  • mave-tarm irritation
  • nyresvigt (renal insufficient)
  • hududslæt
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6
Q

Mekanisme:

Mavesår

A

NSAID:

  • lokalirriterende på ventrikelslimhinden
  • hæmmer prostaglandiner (som beskytter slimhinden)
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7
Q

Hvornår bruges:

immunsupprimerende stoffer

A
  • nedsætte ledgigts processen (nedsætte hævelser)
  • efter organ transplation
  • efter knoglemarvs transplation
  • ved autoimmune sygedomme
  • inflammatoriske tarmsygdomme
  • hudsygedomme
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8
Q

Hvornår bruges:

NSAIDs

A
  • anti-trombin (blodfortyndende)
  • smertestillende (kort tid -> hovedpine, lang tid -> kronisk smerte)
  • anti-inflammatorisk (gigt)
    febernedsættende
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9
Q

Behandling af:

Tuberkolose

A

Kombinations behandling:

  • isoniazid: dræber mycobakterier i host cells
  • rifamoicin: hæmmer mycobakteriers RNA polymerase
  • pyrazinamide: dræber mycobakterier -> og giver lever svigt
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