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Immunology and Haematology > Immune therapies > Flashcards

Immune therapies Flashcards

1
Q

Give three examples of monoclonal antibodies

A

Rituximab
Infliximab
Trastuzumab

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2
Q

Describe the mechanism of rituximab. What diseases is it most commonly used to treat?

A

Targets B-cells expressing CD20 molecule on the surface

Used for non-Hodgkin lymphoma, RA and SLE

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3
Q

Describe the mechanism of infliximab. What diseases is it most commonly used to treat?

A

Anti-TNF chimeric antibody, used to treat RA, ankylosing spondylitis, Crohn’s and UC

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4
Q

Describe the mechanism of trastuzumab. What diseases is it most commonly used to treat?

A

(brand name Herceptin)
Binds HER2 receptor on cancer cells
Used for HER2+ breast cancer

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5
Q

What is the function of IL-2?

A

activates T-cells

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6
Q

Give two pro-inflammatory cytokines

A

IL-1

TNF-alpha

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7
Q

What is the function of IFM-gamma?

A

phagocyte intracellular killing activity

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Immunology and Haematology (11 decks)

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