Immune System and Blood Flashcards
Function of the Immune System
Defend the body against foreign invaders.
Must be able to discriminate between the
body’s own cells and tissues versus
foreign material.
An Antigen is :
any object or substance that is
perceived as foreign and therefore elicits
an immune response.
Antibodies are:
proteins produced by B cells in response to an antigen.
A Pathogen is:
microorganisms and parasites that cause disease.
Examples Barrier Defenses:
- Skin
- Tears and saliva have lysozyme
- The respiratory tract has cilia and mucus
- The stomach acids
- Beneficial bacteria
- Acidic urine
The _______ is an excellent barrier keeping
many things out of the body
skin
_____ and ______ have lysozymes which are enzymes that can kill bacteria.
Tears and saliva
The respiratory tract has _____ and _____ that help to transport foreign
things out of the respiratory system
cilia and mucus
The_______ has acids that help kill bacteria
stomach
Beneficial bacteria in the _____ and ______ out compete harmful
bacteria
large intestine and vagina
Acidic urine kills bacteria and washes bacteria from the _____
urethra
Which of the following is not a barrier defense?
- Skin
- Tears
- Antibodies
- Stomach acid
- Antibodies
Two Types of Immune Defense:
Nonspecific defenses
Specific defenses
Nonspecific defenses are:
Parts of the immune system that attack
any antigen (cell or object it identifies as
foreign)
Specific defenses are:
Other immune cells will only respond to
one particular antigen
Which defense leads to acquired immunity:
Specific defenses
acquired immunity definition:
a long lasting protection from that particular antigen
Non Specific Defenses examples:
- Immune system cells
- Inflammatory response
- Proteins
If our body comes in contact with an antigen,
it “remembers” that antigen so the next time __________
it comes in contact with it, the body can quickly
mount a defense.
To defend against foreign invaders, the body needs to ________
identify its own cells.
All the cells in your body have proteins in their plasma membrane that ______
identify it as part of you body.
The proteins in the plasma membrane that identify it as part of your
body are called : _______
major histocompatibility complex (MHC) markers
Your MHC markers are ______
unique to you
In the specific defenses there are two ways
we fight invaders what are they:
Antibody-mediated immunity , Cell-mediated immunity
B cells are examples of :
Antibody-mediated immunity
T cells are examples of :
Cell-mediated immunity
There are two types of specific defense
lymphocytes they are:
B Cells - specific defense
T Cells - specific defense
T cells are produced in the _____
bone marrow
T-cells travel to the ______ where they develop into mature T Cells.
thymus
T cells are important in the ________ of our acquired immunity.
cell-mediated part
B cells are produced in the ______-
bone marrow
Where do B cells mature?
The bone marrow
B cells are important in _______-
antibody-mediated immunity
Both mature B cells and T cells will go to the
______ and ______
lymphatic system and the circulatory system
Where are lymphocytes produced?
- Spleen
- Thymus
- Lymph nodes
- Bone
- Bone
An object that is perceived as foreign and illicits an immune response. 1. Pathogen 2. Antigen 3. Antibody
- Antigen
Antibodies are :
proteins that circulate through
the body and bind onto a particular antigen
(foreign object)
Antibodies start out as ______ on the
surface of _____. The antibody is specific –
it only bind with one type of antigen.
receptors , B cells
Antibodies are released from _____ and circulate throughout the body.
B cells
What process produces RNA?
A. Replication
B. Translation
C. transcription
C. transcription
An antibody is specific to a particular _________
antigen
The B cells have DNA sequences that are constantly being ______ to create new B cells with new types of receptors.
“shuffled”
DNA is transcribed to make ______
mRNA
mRNA is translated to make _______
proteins
each B cell only have _____ type of receptor.
one
When a B cell receptor comes into contact with the antigen it is specific for, the B cell starts to ___________
make identical copies of itself through mitosis
The copies B cells start to make are called clones also known as ______
clonal selection.
Some of these B cells will shed their receptors called:
Plasma cells
Other B cells will keep their receptors, and will remain in the body, ready to defend against the antigen in the future these are called:
Memory cells
B cells are produced in the _______ and _______ in the bone marrow
bone marrow, mature
B cells have receptors in the _______
plasma membrane
B cells that shed their receptors are ________
plasma B cells
B cells that keep their receptors and remain in the blood are ______
memory B cells
The antibodies that are free floating in your body will _____ to the ______
bind to the antigen
Effects of Antibodies Binding to Antigen:
To mark it so the body knows to destroy it with its
________
nonspecific defenses
Effects of Antibodies Binding to Antigen:
Attracts _______ to the area that will engulf and destroy the antigen
phagocytes
Effects of Antibodies Binding to Antigen:
Coats the ______, making it easier to phagocytize.
antigen
Effects of Antibodies Binding to Antigen:
Binds the antigens, causing them to clump together –
this will cause them to _______
fall out of solution.
Effects of Antibodies Binding to Antigen
Neutralize ______ and ________
toxins and viruses.
Effects of Antibodies Binding to Antigen
Activate the _______ which cause the bacteria to lyse open.
complement proteins
T cells are important players in _____ immunity
cell-mediated immunity.
There are two types of T cells
Helper (CD4) T cells
Killer (cytotoxic) T cells
Macrophages can also be ________ which pick up antigens (foreign material) and they bring them to the lymph nodes and the spleen.
antigen presenting cells (APCs)
The _______ and _______ store huge numbers of immune system cells.
lymph nodes and spleen
What does it mean when a helper T cell is activated?
it starts to make copies or clones of itself.
The helper T cells activate _______ to also start making clones
cytotoxic T cells
How does a helper T cell become activated?
When a helper T cell meets a APC cell with the correct antigen
The helper T cells activate ______-
B cells
The _____ T cells kill the cancer cells and infected cells or organ transplant cells
cytotoxic T cells
These B cells shed their receptors, making
antibodies
1. Memory cells
2. Plasma cells
- Plasma cells
T cells are produced in the
- Bone
- Thymus
- Thyroid
- Spleen
- Bone
These cells are important in the antibody mediated response
A. T cells
B. B cells
B. B cells
B cells mature in the : A. bone B. Thymus C. Thyroid D. Spleen
A. bone
Where are T cells produced: A. Bone B. thymus C. Thyroid D. Spleen
A. Bone
Immune system cells examples:
A. Neutrophils B. Monocytes/Macrophages C. Basophils and mast cells D. Eosinophils E. Natural killer cells
When the body is injured or damaged then the body mounts an ________
inflammatory response.
Mast cells in the tissue release _______
histamines.
Histamines cause:
blood vessels to dilate and make the vessels more permeable
Increased blood flow causes increased _________
temperature and redness.
In an inflammatory response, The blood vessels are more _____ so the defense cells, fluid and proteins can pass out of the vessels to the site of injury.
permeable
Platelets Function:
aid in blood clotting
White Blood Cells (WBC) function –
fight infection
Red Blood Cells (RBC) function:
carry oxygen
Stem cells ________
give rise to all the formed elements
Stem cells are located in the _________
red bone marrow
Platelets, WBCs, and RBCs are examples of ______ elements
formed
Platelets are also called ________
thrombocytes
Platelets are fragments of larger precursor cells called _______
megakaryocytes
Platelets Function:
Essential to blood clotting
In the inflammatory response, these cells in the tissue release histamines A. T cells B. B cells C. Mast cells D. Basophils E. Eosinophil F. Neutrophil G. Erythrocyte H. Monocyte I. Lymphocyte
C. Mast cells
Histamines have this effect on blood vessels:
A. Dilate
B. constrict
A. Dilate
Histamines have this effect on blood vessels:
they cause them to be more or less leaky
(permeable)
A. More
B. Less
A. More
Platelets play a role in _______
blood clotting
White blood cells (WBCs) – also called _________
leukocytes
White blood cells (WBCs) Functions:
Help defend the body against disease
Remove wastes, toxins, and damaged and
abnormal cells
Some white blood cells, squeeze through pores in the capillary
wall therefore are also found in ____ fluid and in______
tissue, lymphatic system
Neutrophils are the ______
Most abundant
Which type of white blood cell is the first to respond to an infection:
Neutrophil
Phagocytes function:
engulf microbes (bacteria).
Eosinophils Defend against ________
parasitic worms
Eosinophils Lessen the severity of ________ and _______
allergies and asthma
Basophils Release ________
histamine
Histamine is a a chemical that __________
attracts other white blood cells
Histamine Causes the blood vessels to _____ and become more _____
dilate, permeable
Basophils Also play a role in some _________
allergic reactions
Mast cells are similar to basophils but are found in ______
tissues
Monocytes is the ______ of the formed elements
largest
Monocytes develop into _______
macrophages
macrophages are:
Phagocytic cells that engulf invading
microbes, dead cells, and cellular debris
Three types of Lymphocytes :
- B-cells protect us by producing antibodies
- T-cells destroy any cell that is foreign
- Natural Killer cells attack virus infected cells
and tumor cells
These WBCs release histamines
- Eosinophils
- Basophils
- Neutrophils
- Lymphocytes
- Basophils
These WBCs fight parasite infections
- Eosinophils
- Basophils
- Neutrophils
- Lymphocytes
- Eosinophils
The largest WBCs are
- Lymphocyte
- Eosinophils
- Monocytes
- Neutrophils
- Monocytes
Red blood cells (RBCs) are also called ______
erythrocytes
RBCs are the _______ of the formed elements
Most numerous
RBCs transport ________ to the rest of the cells
oxygen
RBC’s carry about _____ of the total carbon dioxide
23%
RBCs are shaped like ________ and are very flexible
biconcave disks
Mature RBCs have no ______
nucleus
RBCs contain _____-
Hemoglobin
Hemoglobin is a protein that binds to _____, making oxyhemoglobin
oxygen
When the body detects a low level of oxygen, the kidneys produce a hormone called _____
erythropoietin
The kidneys release erythropoietin when:
body detects a low level of oxygen
Erythropoietin is a hormone that ________
speeds up maturation of stem cells that are in the process of becoming RBC.
The target of erythropoietin is ________
the bone marrow, where red blood cells are formed
What hormone increases production of RBC
- Renin
- Erythropoietin
- Leptin
- RBCH
- Erythropoietin
Which of the following produces erythropoietin
- Bone marrow
- Kidneys
- Anterior Pituitary
- Hypothalamus
An object that is perceived as foreign and elicits an immune response is a(n)
A. Pathogen
B. Antibody
C. Antigen
C. Antigen
Which of the following cells produce antibodies?
A. B cells
B. neutrophils
C Natural Killer Cells
D T cells
A. B cells