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Patho Exam 2 Spring 2014 > Immune response > Flashcards

Immune response Flashcards

1
Q

What releases arachidonic acid?

A

Bradykinin

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2
Q

What releases arachidonic acid?

A

Bradykinin

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3
Q

What does arachidonic acid release?

A

Prostaglandins
Leukotrienes
Thromboxanes

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4
Q

What cells are involved in humoral immunity?

A

B Cells

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5
Q

What do basophils store?

A

Chemical mediators

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6
Q

What is the job of thromboxanes?

A

Clotting

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7
Q

What is related to leukotriene action?

A

Arthralgia and myalgia

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8
Q

What produces antibodies?

A

Plasma cells

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9
Q

What substance initiates the inflammatory response?

A

Haegman Factor

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10
Q

Function of interleukins?

A

stimulate T and B cells
cause fever, myalgia, arthralgia, slow wave sleep
increase activity of b cells, cytotoxic cells, NK
stimulate the production of more t cells

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11
Q

Major histocompatibility complex

A

Distinguish self from nonself

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12
Q

What is responsible for fever, myalgia, joint pain?

A

Interleukins

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13
Q

What is a type of myelocyte?

A

Basophil

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14
Q

How long does it take to make antibodies?

A

several days

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15
Q

Neoplasms occur when?

A

when mutant cells escape the immune system and multiply

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16
Q

What cells stimulate other cells to be more aggressive?

A

T helper cells

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17
Q

What immunoglobin is the first to be released upon exposure to an antigen?

A

IgM

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18
Q

Full thickness body burns can cause what barriers to be destroyed?

A

Skin & Mucous membranes

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19
Q

How many immunoglobins are there?

A

5

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20
Q

Complement proteins form a ring around an antigen and do what?

A

alter the antigens membrane
release histamine
induce chemostaxis
increase phagocyte activity

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21
Q

Gold salts inhibit what?

A

Phagocytes

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22
Q

NSAIDS inhibit what?

A

Prostaglandins

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23
Q

Salicylates block what?

A

Prostaglandin activity

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24
Q

When can a pt who underwent surgery begin taking aspirin again?

A

1 week (7 day)

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25
How is etanercept given?
SQ
26
What agent is contraindicated for a pt allegic to tartrazine?
Aspirin
27
What is injected into the knee to prevent arthritis?
Hyaluronidase
28
How long does it take for penicillamine to take effect?
2-3months
29
Acute salycilate toxicity signs?
Hyperpnea Excitement Tetany
30
When is gold salts contraindicated?
DM HTN Blood dyscrasias
31
Celebrex is contraindicated in?
Sulfa allergies
32
Are there drug to drug interactions for interleukins and interferons?
No
33
Which drug causes t cells to be disabled?
Muromomab-CD3
34
What is an adverse effect of monoclonal antibodies?
Pulmonary edema
35
What is an adverse to immune stimulants?
flu like symptoms
36
What is the most common immune suppressant?
Cyclosporine
37
What can you mix cylcosporine with?
Orange juice, milk, chocolate milk
38
Immune sera
bacterial antibodies in serum
39
Vaccines are available for what biological weapons?
Anthrax, smallpox, botulism
40
What do you give immune globulin for?
Bite from an animal w/rabies
41
Adverse effects of immunizations?
irritability anorexia chills redness at site
42
Vaccines are what type of immunity
active
43
Example of passive immunity
antibodies injected in host
44
Tx for botulism
Immune sera
45
With what does serum sickness occur
immune sera
46
Caution for vaccines if pt has what?
Febrile
47
What does arachidonic acid release?
Prostaglandins Leukotrienes Thromboxanes
48
What cells are involved in humoral immunity?
B Cells
49
What do basophils store?
Chemical mediators
50
What is the job of thromboxanes?
Clotting
51
What is related to leukotriene action?
Arthralgia and myalgia
52
What produces antibodies?
Plasma cells
53
What substance initiates the inflammatory response?
Haegman Factor
54
Function of interleukins?
stimulate T and B cells cause fever, myalgia, arthralgia, slow wave sleep increase activity of b cells, cytotoxic cells, NK stimulate the production of more t cells
55
Major histocompatibility complex
Distinguish self from nonself
56
What is responsible for fever, myalgia, joint pain?
Interleukins
57
What is a type of myelocyte?
Basophil
58
How long does it take to make antibodies?
several days
59
Neoplasms occur when?
when mutant cells escape the immune system and multiply
60
What cells stimulate other cells to be more aggressive?
T helper cells
61
What immunoglobin is the first to be released upon exposure to an antigen?
IgM
62
Full thickness body burns can cause what barriers to be destroyed?
Skin & Mucous membranes
63
How many immunoglobins are there?
5
64
Complement proteins form a ring around an antigen and do what?
alter the antigens membrane release histamine induce chemostaxis increase phagocyte activity
65
Gold salts inhibit what?
Phagocytes
66
NSAIDS inhibit what?
Prostaglandins
67
Salicylates block what?
Prostaglandin activity
68
When can a pt who underwent surgery begin taking aspirin again?
1 week (7 day)
69
How is etanercept given?
SQ
70
What agent is contraindicated for a pt allegic to tartrazine?
Aspirin
71
What is injected into the knee to prevent arthritis?
Hyaluronidase
72
How long does it take for penicillamine to take effect?
2-3months
73
Acute salycilate toxicity signs?
Hyperpnea Excitement Tetany
74
When is gold salts contraindicated?
DM HTN Blood dyscrasias
75
Celebrex is contraindicated in?
Sulfa allergies
76
Are there drug to drug interactions for interleukins and interferons?
No
77
Which drug causes t cells to be disabled?
Muromomab-CD3
78
What is an adverse effect of monoclonal antibodies?
Pulmonary edema
79
What is an adverse to immune stimulants?
flu like symptoms
80
What is the most common immune suppressant?
Cyclosporine
81
What can you mix cylcosporine with?
Orange juice, milk, chocolate milk
82
Immune sera
bacterial antibodies in serum
83
Vaccines are available for what biological weapons?
Anthrax, smallpox, botulism
84
What do you give immune globulin for?
Bite from an animal w/rabies
85
Adverse effects of immunizations?
irritability anorexia chills redness at site
86
Vaccines are what type of immunity
active
87
Example of passive immunity
antibodies injected in host
88
Tx for botulism
Immune sera
89
With what does serum sickness occur
immune sera
90
Caution for vaccines if pt has what?
Febrile

Patho Exam 2 Spring 2014 (4 decks)

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