Immune cell generation Flashcards
What precursor cell are all immune cells derived from?
pluripotent stem cells
Where are pluripotent stem cells generated?
Bone marrow
What does pluripotent mean?
Gives rise to all cell types in the adult lineage (all adult cells)
What 2 precursor cells do pluripotent stem cells divide into?
Common lymphoid progenitor, common myeloid progenitor
What cell system is the common lymphoid progenitor the precursor of?
Adaptive immune cells
What are the adaptive immune cells?
T cells and B cells
What cell system is the common myeloid progenitor cell the precursor of?
Innate immune cells
What precursor cells does the common myeloid progenitor divide into?
Megakaryoblast, Myeloblast, Proerythroblast, Monoblast
What does a megakaryoblast differentiate into, and what is it’s function?
Megakaryocyte, which produces platelets
What 5 cells does a myeloblast differentiate into?
Neutrophil, eosinophil, dendritic cell, mast cell, basophil
What cell lineage/class does the myeloblast differentiate into?
Granulocyte
What does the proerythroblast differentiate into?
Erythrocyte (RBC)
What is the function of a neutrophil?
Phagocytosis
What 3 substances are released from a basophil?
Histamines, IL-13,IL-14
In what 2 conditions does a basophil secrete substances?
Allergic reaction, parasitic infection
What kind of infection does a eosinophil protect against?
parasitic
What do dendritic cells become when they meet a pathogen/antigen?
Antigen Presenting Cell
In what kind of reaction are mast cells active?
Allergic reaction
What does a monoblast differentiate into?
Monocyte
When does a monocyte differentiate into a macrophage?
When it is transported to a tissue
