Immune APM Flashcards
NFKB activation
triggered by inflammation, binds regulatory region of inflammatory genes, increasing inflammation
activation triggers TNF, IL1, IL6, LOX and COX pathways
(Incorrect regulation of NF-κB linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development)
nutritional interventions for patients with autoimmune
dietary
fiber low sodium Mediterranean diet fasting paleo ReNew Food Plan elemental diet limit nightshades
nutrient interventions for patients with autoimmune
Fatty acid
4-5 omega 6: omega 3 ratio (lowers competition for D6D and reduces shunting to AA)
how does EPA block metabolism of AA
inhibits delta 5 desaturase
Coenzymes for desaturase of omega 3 FA
Zinc Mag vit C niacin pyridoxine
Factors that inhibit delta-6-desaturase (D6D)
alcohol, aging, diabetes, radiation
Acute phase response in acute and chronic inflammation: hepatic plasma proteins
CRP (rapid increase)
coagulation proteins (slow increase): fibrinogen, prothrombin, complement, ferritin, haptoglobin, ceruloplasmin
Acute phase response in acute and chronic inflammation: what happens to CBC?
Leukocytosis
Thrombocytosis
What happens to NFKB in acute and chronic inflammation?
activated
what happens to iron and zinc in acute and chronic inflammation?
decrease
what happens to albumin, transferrin, antithrombin, AFP, IGF-1, TBG in acute and chronic inflammation?
decrease
which conditions have ESR > 100?
SLE PMR temporal arteritis RA IBD multiple myeloma Hodgkin's CKD
when is NK cytotoxic activity decreased?
aging CA chemo chronic viral infxn CFS inflammation autoimmunity obesity cigarette smoking chronic stress EPA
Botanicals with anti-inflamm properties
willow bark licorice boswellia bromelain Chinese skullcap turmeric ginger cayenne aloe green tea
Botanicals/phytochemical COX modulators
bromelain capsaicin carnosol (rosemary) Chinese skullcap turmeric feverfew gingerol green tea melatonin trans-resveratrol thymol willow bark
