Immune and Lymphoid Flashcards
Immunocompetent cell
Cell that is able to recognize antigens and act against them
Immune response
How the body recognizes and defends against foreign substances and pathogens
Humoral immunity
Acquired immunity in which antibodies are secreted in response to antigenic stimulation.
cellular immunity
Immunological defense provided by T cells that come into close contact with their victim cells
Plasma cells
Cells derived from B lymphocytes that produce and secrete large amounts of antibodies. Responsible for humoral immunity
Memory cells
Cells derived from B or T cells that can quickly recognize a foreign antigen to which the body has been previously exposed.
Antigen-presenting cell (APC)
Immunocompetent cell that mediates the cellular immune response by processing and presenting antigens to T cells.
Waldeyer’s Ring
Pharyngeal, palatine and lingual tonsils which form a circle at entrance of gut and airway. Strategic, primary defense of lymphoid tissue
Peyers patches
Group of lymphoid nodules in the mucosa of the ileum that respond to foreign antigens.
Immunoglobulin/Antibody
Protein produced by B cells in response to unique antigen.
Antigen
Any substance that causes the immune system to produce antibodies against it.
Innate (natural) immunity
Most primitive an fast. Little specificity (programmed in germ line DNA). Results in direct killing of pathogens via macrophages, neutrophils, eosinophils and NK. Dysfunctional activation can lead to autoimmune dieases.
Adaptive immunity
Antigen specific immune response.
Immunodeficiency
Decreased or compromised ability to respond to antigenic stimuli with an appropriate immune response.
Follicular Cortex of lymph node
- Rich capillary network
- B-cell zone
Parafollicular cortex of lymph node
- Deep cortex
- Rich capillary network
- T-cell zone
Medulla of lymph node
- Rich with cells (macrophages, dendritic, pasta and B).
- Highly branched network of thin reticular fibers provide physical support and network for mov’t of lymphocytes and dendritic cells
Cortical sinuses
- Receive fluid from afferent vessels.
- Composed of trabecular, cortical and intermediate sinuses.
- Contains macrophages and dendritic cells to perform phagocytosis.
Medullary sinuses
- Collect lymph after filtration in cortez
- Contains macrophages and antibodies
Medullary cords
Contains the plasma cells that secrete antibodies into sinuses
Red pulp
More abundant, main filtration functions.
White pulp
Lymphatic nodules and diffuse lymph tissue. Synthesizes antibodies.
Splenic Cords
Found in red pulp between sinusoids. Hold monocytes.
Splenic Sinusoids
Endothelial cells arranged loosely in tubular form. Blood moves easily in and out as discontinuous.
Thymus
- Production of T lymphocytes
- Hormone secretion
Thymus outer cortex
Full of developing thymocytes and macrophages
Thymus medulla
Full of T cells
Hassal’s corpuscles
Concentric, flattened epithelial reticular cells
