Immune

Question 1

IBS, Depression, recent ankle fractures - what are you suspicious of

Answer 1

celiac disease *associated with osteoporosis

Question 2

Ankylosing spondylitis (AS) may be caused by an inappropriate immune response to what pathogen?

Answer 2

klebsiella pneumonia

Question 3

what photochemcials and botanicals act as NF-kappaB (NFkB) inhibitor

Answer 3

Vitamin C, B12, and ALA, turmeric

Question 4

What is the mechanism of quercetin?

Answer 4

stablizes mast cell membranes and reduces degranulation

Question 5

The activity of delta-6-desaturase (D6D), an enzyme that converts linoleum acid (LA) to GLA is impaired by what?

Answer 5

alcohol

Question 6

The four primary triggers for autoimmune disease are?

Answer 6

Trauma, infection, toxins, and foods. (genes are an antecedent)

Question 7

How does glycemic lost increase inflammation?

Answer 7

via NF kB activation it can increase hsCRP

Question 8

Which botanicals function as NF-kappaB inhibitor?

Answer 8

Tumeric (curcuma longa)

Question 9

Which fatty acid inhibits delta‐5‐desaturase?

Answer 9

Eicosapentaenoic acid (EPA)

Question 10

A 43‐year‐old female with early rheumatoid arthritis is interested in adding one supplement to her diet that would help with her symptoms. She has already started a modified elimination food plan. Which is her best choice?

Answer 10

Omega 6
Borage, EPO (GLA)

Omega 3
flax, walnut, chia, hemp, soy (omega 3)
fish (EPA), fish/algae (DHA)

Question 11

botanicals/phytonutrients with COX modulatory Properties

Answer 11

Bromelain, cayenne, ginger, rosemary, green tea, skullcap, teas-resveratrol, turmeric, feverfew, willow bark

Question 12

A 38‐year‐old female comes in with a diagnosis of lupus. You run a high‐sensitivity C‐reactive protein (hs‐CRP) and find that it is elevated. You place the patient on an elimination diet and also select two botanicals to decrease inflammation through their activity on cyclooxygenase (COX) enzymes. You choose

Answer 12

Bromelain and Ginger

Question 13

A 15‐year‐old male presents to your clinic with a history of asthma and an identified environmental trigger of grass pollen. Which foods could also exacerbate his asthma because of pollen‐food antigen crossover reaction?

Answer 13

Potatoes, tomatoes, and peaches

Question 14

A 26‐year‐old male presents to your clinic with concerns about gluten sensitivity. His mother and uncle both have biopsy‐proven celiac disease. He has been off gluten for three months. He brings in lab results that show negative serum anti‐endomysial and deaminated anti‐gliadin antibody tests. In order to rule out celiac disease in this individual, you recommend

Answer 14

HLA DQ2 and DQ8

Question 15

You are treating a 35‐year‐old female for psoriatic arthritis. You have made dietary changes and started her on EPA/DHA and vitamin D. You want to add two botanicals that act as anti‐inflammatories. The best choices are:

Answer 15

boswellia and bromelian

Question 16

Molecular mimicry results in

Answer 16

Development of autoimmunity

Question 17

An elimination diet, completed for a minimum of four weeks, addresses:

Answer 17

The clearance of IgE and IgG from the serum

Question 18

A 27-year-old male presents with chronic inflammation. You want to modulate the inflammatory cascade. Which combination of interventions would be useful to block phospholipase A2?

Answer 18

Vitamin E and quercetin

Question 19

A 37-year-old female patient presents with a chief complaint of an expanding list of food sensitivities that seem to be triggering eczema outbreaks. Which of the following is the most likely underlying cause of her eczema outbreaks?

Answer 19

Insufficient HCL production

Question 20

Select the statement that best describes the relationship of eicosapentaenoic (EPA) and docosahexaenoic (DHA) with systemic inflammation

Answer 20

EPA and DHA both reduce inflammation.

Question 21

Which of the following is most likely to stimulate NF-kappa-B production?

Answer 21

lipopolysaccarides

Question 22

Which of the following is a downstream metabolite of alpha-linolenic acid?

Answer 22

Eicosapentaenoic acid

Question 23

Which of the following are most likely to inhibit delta-6-desaturase enzymes?

Answer 23

Alcohol

Question 24

An elimination diet should be instituted for three to four weeks

Answer 24

Because the half-life of IgG antibodies in the serum is about 23 days.

Question 25

Is celiac disease associated with fracture risk?

Answer 25

yes via osteoporosis/malabsoption