Immune Flashcards
IBS, Depression, recent ankle fractures - what are you suspicious of
celiac disease *associated with osteoporosis
Ankylosing spondylitis (AS) may be caused by an inappropriate immune response to what pathogen?
klebsiella pneumonia
what photochemcials and botanicals act as NF-kappaB (NFkB) inhibitor
Vitamin C, B12, and ALA, turmeric
What is the mechanism of quercetin?
stablizes mast cell membranes and reduces degranulation
The activity of delta-6-desaturase (D6D), an enzyme that converts linoleum acid (LA) to GLA is impaired by what?
alcohol
The four primary triggers for autoimmune disease are?
Trauma, infection, toxins, and foods. (genes are an antecedent)
How does glycemic lost increase inflammation?
via NF kB activation it can increase hsCRP
Which botanicals function as NF-kappaB inhibitor?
Tumeric (curcuma longa)
Which fatty acid inhibits delta‐5‐desaturase?
Eicosapentaenoic acid (EPA)
A 43‐year‐old female with early rheumatoid arthritis is interested in adding one supplement to her diet that would help with her symptoms. She has already started a modified elimination food plan. Which is her best choice?
Omega 6
Borage, EPO (GLA)
Omega 3
flax, walnut, chia, hemp, soy (omega 3)
fish (EPA), fish/algae (DHA)
botanicals/phytonutrients with COX modulatory Properties
Bromelain, cayenne, ginger, rosemary, green tea, skullcap, teas-resveratrol, turmeric, feverfew, willow bark
A 38‐year‐old female comes in with a diagnosis of lupus. You run a high‐sensitivity C‐reactive protein (hs‐CRP) and find that it is elevated. You place the patient on an elimination diet and also select two botanicals to decrease inflammation through their activity on cyclooxygenase (COX) enzymes. You choose
Bromelain and Ginger
A 15‐year‐old male presents to your clinic with a history of asthma and an identified environmental trigger of grass pollen. Which foods could also exacerbate his asthma because of pollen‐food antigen crossover reaction?
Potatoes, tomatoes, and peaches
A 26‐year‐old male presents to your clinic with concerns about gluten sensitivity. His mother and uncle both have biopsy‐proven celiac disease. He has been off gluten for three months. He brings in lab results that show negative serum anti‐endomysial and deaminated anti‐gliadin antibody tests. In order to rule out celiac disease in this individual, you recommend
HLA DQ2 and DQ8
You are treating a 35‐year‐old female for psoriatic arthritis. You have made dietary changes and started her on EPA/DHA and vitamin D. You want to add two botanicals that act as anti‐inflammatories. The best choices are:
boswellia and bromelian
Molecular mimicry results in
Development of autoimmunity
An elimination diet, completed for a minimum of four weeks, addresses:
The clearance of IgE and IgG from the serum
A 27-year-old male presents with chronic inflammation. You want to modulate the inflammatory cascade. Which combination of interventions would be useful to block phospholipase A2?
Vitamin E and quercetin
A 37-year-old female patient presents with a chief complaint of an expanding list of food sensitivities that seem to be triggering eczema outbreaks. Which of the following is the most likely underlying cause of her eczema outbreaks?
Insufficient HCL production
Select the statement that best describes the relationship of eicosapentaenoic (EPA) and docosahexaenoic (DHA) with systemic inflammation
EPA and DHA both reduce inflammation.
Which of the following is most likely to stimulate NF-kappa-B production?
lipopolysaccarides
Which of the following is a downstream metabolite of alpha-linolenic acid?
Eicosapentaenoic acid
Which of the following are most likely to inhibit delta-6-desaturase enzymes?
Alcohol
An elimination diet should be instituted for three to four weeks
Because the half-life of IgG antibodies in the serum is about 23 days.
Is celiac disease associated with fracture risk?
yes via osteoporosis/malabsoption
