IMMUNE Flashcards
What are IgG?
Immunoglobulin G.
most common antibody
can cross placenta giving passive immunity
what are IgE?
Immunoglobulin E
antibody involved in allergic reactions
releases chemicals that accelerate local inflammation
responsible for mast cell action in allergic reactions
humoral immunity VS cell-mediated immune response
HUMORAL- antibodies- produced by B cells
CELL MEDIATED- phagocytes, antigen specific cytotoxic and lymphocytes, cytokines (various)
what is an antigen? antibody?
ANTIGEN= any molecule capable of stimulating an immune response (can be self-antigen) ANTIBODY= proteins that help the immune system to destroy antigens
what is hypersensitivity?
inappropriate excessive immune responses - allergies. an abnormal/ hyper responsiveness to a normal stimulus
what is autoimmunity?
inappropriate responses to self
basis of an autoimmune disease
what is alloimmunity?
produces an immune response against antigens from the same species. can occur after an allograph (transplant of body tissue) or allotransfusion (plasma, immunoglobulin, plasma products)
what is anaphylaxis?
a severe, potentially life-threatening allergic reaction.
immediate reactions- IgE mediated response
occurs within minutes of exposure
what are some signs and symptoms of anaphylaxis?
vasodilation= low BP uticarcia (hives) = RASH respiratory distress- noisy breathing, wheeze, stridor system shock and death HYPOTENSION AND TACHYCARDIA LOSS OF CONSCIOUSNESS
what is the treatment for anaphylaxis?
ADRENALINE (EPIPEN- if in community) O2 IV ACCESS FLUID REPLACEMENT ANTIHISTAMINES HYDROCORTISONE
what dose of adrenaline should be given to adults?
0.5ml
