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Farmakoloji > İmmun Supresif İlaçlar > Flashcards

İmmun Supresif İlaçlar Flashcards

1
Q

Kalsinörin inhibitörleri

A

IL-2 sentezi inhibisyonu

Siklosporin ve Takrolimus

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2
Q

Siklosporin

A

İnterlokin 2 üretimini inhibe eder
Oral ve İV
LDL ile taşınır
Yan etki nefrotoksiktir ve hiperkalemi yapar

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3
Q

Takrolimus

A

FKBP-12 ye baglarak kalsinörin inh eder ve interlokin 2 üretimini inhibe eder
Siklosporin den daha efektif

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4
Q

Sirolimus(Rapamisin)

A

FK-506 ya baglanir mTOR kinazı bloke eder. Th hücreler prolifere olamaz

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5
Q

Mikofenolat mofetil

A

İnozin monofosfat dehidrogenaz ı inhibe ederek pürin sentezini engelleyen bir ön ilaçtır.

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6
Q

Leflunomid

A

Romatoid artritte kullanilir

Dihidroorotat dehidrogenazı inhibe eder

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7
Q

Muromonab

A

T lenfositteki CD3 e karşı geliştirilmiş monoklonal antikor

Romatoid artrit tedavisinde kullanılabilir

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Farmakoloji (3 decks)

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