Illicit Drugs & Forensic Toxicology Flashcards
- What is the role of a forensic toxicologist?
○ Detection
○ Quantification
○ Interpretation of foreign compounds (xenophobics) in forensic samples
- What are the classification of drugs?
○ Legislation (Schedules)
○ Therapeutic class/actin/receptor : (opiod analgesic, antidepressant, stimulant, B blockers, sedative, etc.)
○ Broad chemical properties: acid (carboxylic acid), vase (amine), polar, non-polar.
How are drugs legally classified?
They are classified based on the schedules they fall under
Name and identify each schedule and what they represent?
Schedule 2,3,4,5,6,7,8,9
2 Pharmacy medicine or at licenced dealer: Antihistamine, Paracetamol.
3 Pharmacy ONLY w verbal advise.
Public access without prescription.
4 Doctor’s Prescription ONLY: Antidepressants, codeine, antipsychotic.
5 Caution substances- Low harm potential Requires clear labelling.
6 Poison
7 Dangerous poison
8 Controlled drug- drugs of dependence: Morphine, Oxycodone, Fentanyl, Alprazolam.
9 Prohibited drugs: Heroin, Cocaine, LSD, NPS
Which one is not a prohibited drug? Heroin, Cocaine, LSD, NPS, Morphine
Morphine is a controlled drug
Which one is not a controlled drug? Morphine, Cocaine, Oxycodone, Fentanyl, Alprazolam.
Cocaine is a prohibited drug
What are the main issues leading to the regulation and control of therapeutic and illicit drugs?
SAFETY
Psychological harm
Physical harm
Personal and societal harm
What are the current drug problems in Australia?
*Alcohol 3000 deaths/year.
- Prescription drug abuse:
- Benzodiazepines sedative/anti-anxiety:
- Xanax (Alprazolam)
- Temazepam
- Diazepam (Valium) - Opiates:
- morphine
- Oxycodone
- Codeine
- Fentanyl
*Illicit drugs: • Methamphetamine • MDMA (ecstasy) • Cannabis (THC) • Opiates (heroin) • New psychoactive substances
Which one does not apply for a prescription drug abuse?
- Benzodiazepines sedative/anti-anxiety:
- Xanax (Alprazolam)
- Temazepam
- Diazepam (Valium) - Opiates:
- morphine
- Oxycodone
- Codeine
- Fentanyl
- Heroin
- Heroin is a prohibited drug
What are Analgesic drugs? select the incorrect one. Codeine Fentanyl Hydrocodone Cannabis Meperidine
Cannabis is illicit drug- gives pleasure and CNS depressant- slows down brain activity.
- What is the difference between a pharmacologist and an analytical toxicologist?
○ Pharmacologist: Provides opinions on effects and interactions of the drugs.
○ Analytical toxicologist: Has a more general interpretation and literature value of the drug.
Pharmacology is the scientific discipline that studies the mechanisms by which drugs alter biological systems in an attempt to improve health and alleviate disease, whereas
Toxicology is the study of mechanisms by which drugs and chemicals in the environment produce unwanted effects.
What are the different work types that use biological samples?
Police samples
Coronial
Traffic
- What is the extraction methods for analysing and detecting drugs?
Sample Prep:
• Solid phase Extraction e.g. morphine.
• Liquid-liquid extraction- eg common basic drugs
• Protein Precipitation- eg alcohol.
Analysis Instrumentation:
• Chromatography: Separates mixtures into components.
• Mass Spectrometry: Measures & identifies each component.
*Ensures:
•unequivocal identification
•accurate quantification
Where is Chromatography used in?
In analyzing compounds- Separates mixtures into components.
Where is Mass spectrometry used in?
In Analysing compounds- Measures & IDENTIFIES each component.