III. Proteins and Materials

Question 1

Intro - All biomaterials adsrob proteins

Question 2

Intro - Cells never see the bare biomaterial surface

Question 3

Intro - Relevance of protein characterization at surface

Question 4

Intro - Goals

Question 5

Intro - host response to implant surfaces

Question 6

Proteins (Recap.) - Enormous diversity in structure and function

Question 7

Proteins (Recap.) - Can be activated by specific, reversible interactions with other proteins/substrates

Question 8

Proteins (Recap.) - Interaction is regulated by

Question 9

Proteins (Recap.) - amino acids

Question 10

Proteins (Recap.) - Many different properties

Question 11

Proteins (Recap.) - Amino acid sequence determines shape and function of proteins

Question 12

Surface-protein interactions - Formula

Question 13

Surface-protein interactions - Adsorption driven by:

Question 14

Surface-protein interactions - Change in system entropy

Question 15

Surface-protein interactions - Interactions (decreasing strength)

Question 16

Surface-protein interactions - DLVO theory

Question 17

Surface-protein interactions - Protein adsorption kinetics

Question 18

Surface-protein interactions - Properties that determine adsorption

Surface/protein

Question 19

Surface-protein interactions - Adsorption and desorption

Proadsorption/antiadsorption

Question 20

Surface-protein interactions - Vroman effect

Question 21

Surface-protein interactions - Protein corona / conditioning film

Question 22

Surface-protein interactions - Consequences of protein adsorption