IIH L01-L04 Haematology block Flashcards
Which cell does IL-3 promote? L02
Stem cells and their early progenitors
Which cell does IL-5 promote? L02
Eosinophils
Which cell does IL-7 promote? L02
Lymphoid
Which cells degranulate in the acute inflammatory response? L01
Mast cells
What is opsonisation? L01
Process whereby a pathogen is marked for ingestion and destruction by a phagocyte
What are the three mechanisms for opsonisation? L01
Complement, immunoglobulins and CRP & other acute phase proteins
What cells are part of the innate immune system? L01
Neutrophils, monocytes, mast cells and dendritic cells
What cells are part of the adaptive immune system? L01
T and B cells
How does the innate immune system recognise pathogens? L01
Through Pattern Recognition Receptors which recognise the PAMP on the pathogen
What are the features of the adaptive immune system? L01
Highly specific, memory, takes 4-6 weeks
Where do T-cells develop? L01
Thymus
Where do B-cells develop? L01
Bone marrow
Where specifically do B cells mature in response to T cell antigen presentation? L01
Germinal centres and lymph nodes
What is the life span for granulocytes? L02
<48 hours
What is the life span for erythrocytes? L02
120 days
What is the life span for platelets? L02
10 days
What cells are part of the myeloid lineage? L02
Granulocytes (neutrophils, eosinophils, basophils), erythrocytes, monocytes and macrophages
What cells are part of the lymphoid lineage? L02
NK cells, T cells and B cells
What do NK cells do? L02
Part of innate immune system, defend from tumours and virally infected cells
What immunity do T cells cause? L02
Cell-mediated immunity
What immunity do B cells cause? L02
Humoral
What are the original pre-cursors to all blood cells called? L02
Haemopoeitic stem cells
What type of ‘-potent’ are haemopoeitic stem cells? L02
Multipotent as they have the capacity to differentiate into cells of all blood lineages
What is the name of the cell-surface glycoprotein that is an immunophenotypic marker of marrow cells? L02
CD34
