Ig Isotypes Flashcards
1
Q
IgG1 cytokines and properties
A
IFNg and IL-4
Th1 response, opsonization, best for ADCC, response to protein Ag
2
Q
IgG2 cytokines and properties
A
IFNg and TGFb
Antipolysaccharide ab, latest to reach adult level
3
Q
IgG3 cytokine and properties
A
IFNg
Shortest t1/2 (8 days), opsonization
4
Q
IgG4 cytokines and properties
A
IL-4, IL-13
Antipolysaccharide Ab, elevated in immunotherapy
5
Q
IgM properties
A
Best at complement fixation
Primary response (eg isohemagluttinin, RF), neutralizes Ag
6
Q
IgA1 cytokine and location
A
TGFb, IL-5
Serum and respiratory tract
7
Q
IgA2 cytokine and location
A
TGFb and IL-5
Lower GI tract
8
Q
IgE cytokine and properties
A
IL-4 and IL-13
Only Ig to bind to mast cells, binds R with highest affinity
