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Module 7: Mali: ID > ID Pharm Chart > Flashcards

ID Pharm Chart Flashcards

1
Q 
What drug is part of the class Antimalarial
4-aminoquinolone
A

Chloroquine

sulfate

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2
Q

MOA Chloroquine

sulfate

A

Increases
accumulation of
toxic free heme
in parasite

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3
Q

indications of Chloroquine

sulfate

A

P. vivax,
P. ovale,
P. malariae

sensitive P. falciparum
malaria

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4
Q

What drug class is Iodoquinol

A

Antiamebacide

halogenated hydroxyquinoline

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5
Q

MOA of Iodoquinol

A

unknown

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6
Q

indications of Iodoquinol

A

acute & chronic intestinal amebiasis

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7
Q

what is an Antiamebocide

Nitroimidazole antibiotic

A

Metronidazole

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8
Q

MOA of Metronidazole

A

disrupts helical DNA structure and causes DNA strand breakage

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9
Q

indications of Metronidazole

A

susceptible anaerobic bacterial & protozoal infxns;

C difficile infxns

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10
Q

what drug class is Mebendazole part of

A

Antihelminthic

Benzimidazole antihelmintic

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11
Q

MOA of Mebendazole

A

inhibits microtubule synthesis

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12
Q

indications of Mebendazole

A

Infxn of hookworm, pinworm, ascariasis trichuriasis

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13
Q

what drug is under the class Antihelminthic?

A

Praziquantel

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14
Q

MOA Praziquantel

A

causes spastic paralysis and tegumental damage in helminthes

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15
Q

Indications Praziquantel

A

schistosome, taenia infxn

several other rarer parasites

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16
Q

Drugs class of Permethrin

A

Antiscabide

Anti-pediculosis & anti-scabicide drug

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17
Q

MOA of Permethrin

A

delays Na ion influx through nerve and cell membrane producing paralysis and death

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18
Q

Indications of Permethrin

A

Tx head louse, scabies

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19
Q

drug class of Nitrofurantoin

A

Urinary antiseptic

Miscellaneous antibiotic

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20
Q

MOA of Nitrofurantoin

A

inhibits several bacterial enzyme

systems (including acetyl CoA) interfering with metabolism & possibly cell wall synthesis

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21
Q

Indications of Nitrofurantoin

A

Px/Tx
urinary tract
infections

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22
Q

Drug class of Acyclovir

A

Nucleoside

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23
Q

MOA of Acyclovir

A

Inhibits viral DNA
synthesis & viral
replication

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24
Q

indications of Acyclovir

A

Mucocutaneous Herpes Simplex (HSV-1 & HSV-2) infections,

VZV infections (varicella, shingles)

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25
Q

what drugs are Nucleosides

A

Famcyclovir

Valcyclovir

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26
Q

MOA of Famcyclovir

A

Inhibits DNA polymerase, selectively inhibiting herpes viral DNA synthesis and replication

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27
Q

Indications of Nucleosides

A 
HSV,
Herpes Zoster (shingles)
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28
Q

MOA of Valcyclovir

A

Inhibits DNA
polymerase;
incorporates into viral
DNA

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29
Q

what are the M2 pump inhibitors

A
  1. Amantadine

2. Rimantadine

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30
Q

MOA of Amantadine

A

Inhibits uncoating of influenza A virus preventing penetration of virus into host;

dopamine agonists

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31
Q

indication of Amantadine

A

Influenza A,

Parkinson’s Disease

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32
Q

MOA of Rimantadine

A

Exact MOA unknown; possibly

inhibits viral uncoating and replication

33
Q

indications of Rimantadine

A

Influenza A

34
Q

what are the Neuroamidase inhibitors

A

Oseltamivir

Zanamivir

35
Q

MOA of Oseltamivir

A

Prodrug converted to active form and inhibits cleaving of virus from cellular envelope preventing release

36
Q

Indications fo Oseltamivir

A

Treatment & prophylaxis

influenza A & B

37
Q

MOA of Zanamivir

A

Inhibits cleaving of virus from cellular envelope preventing release

38
Q

indications of Zanamivir

A

Tx & Px influenza A & B

39
Q

drug class of Ribavarin

A

Misc.

Also Anti- Hep C

40
Q

MOA of Ribavarin

A

Inhibits replication DNA, RNA viruses via inhibition of protein synthesis

41
Q

indications of Ribavarin

A

RSV in infants, Hepatitis C (with peg interferon alfa-2a)

42
Q

Drug class of Lamivudine

A

Antiretroviral Drugs:

Nucleoside reverse transcriptase inhibitor (NRTIs)

43
Q

MOA od Lamivudine

A

Inhibits viral RNA to DNA transcription

44
Q

indications of Lamivudine

45
Q

Drug class of Delavirdine

A

Antiretroviral Drugs:
Non-nuceloside Reverse Transcriptase inhibitors
(NNRTI)

46
Q

indications of Delavirdine

47
Q

MOA of Delavirdine

A

Non-nucleoside reverse transcriptase inhibitor

48
Q

what drug is under the class Antiretroviral Drugs: Protease inhibitors (PIs)

49
Q

MOA of Darunavir

A

Binds to active site of

HIV protease

50
Q

Indications of Darunavir

51
Q

What drug is under the class Antiretroviral Drugs: Fusion Inhibitors

A

Enfuvirtide

52
Q

what is the MOA of Enfuvirtide

A

Inhibits fusion of virus with host cell membrane; blocking entry and subsequent viral replication

53
Q

Indications of Enfuvirtide

54
Q

Drug class of Maraviroc

A

Antiretroviral Drugs:

CCR5 Antagonists

55
Q

MOA of Maraviroc

A

Binds to human CCR5 receptors,

blocking HIV gp120 attachment and preventing cell entry

56
Q

Indications of Maraviroc

57
Q

Drug class of Raltegravir

A

Antiretroviral Drugs:

Integrase Inhibitors

58
Q

MOA of Raltegravir

A

Inhibits HIV integras, preventing viral DNA insertion into host cell DNA

59
Q

Indications of Raltegravir

60
Q

what drug is ALSO in the class Antihepatitis B Drug

** HINT THIS IS A DRUG WE ALREADY SAW

A

Lamivudine

61
Q

MOA of Lamivudine

A

Inhibits reverse transcriptase; incorporates into viral DNA (nucleoside reverse transcriptase inhibitor)

62
Q

Inhibit Lamivudine

63
Q

What drug is in the class Antihepatitis B or C Drug

A

Pegylated Interferon Alfa 2a

64
Q

MOA of Pegylated Interferon Alfa 2a

A 
1. Binds to specific
cell membrane
receptors inhibiting
viral penetration,
translocation,
transcription,
protein processing,
maturation and
release
2. increases
phagocytic activity
macrophages
3. increases number
and survival of
cytotoxic T cells
65
Q

Indications of Pegylated Interferon Alfa 2a

A

HBV, HCV infections

66
Q

weird but what drug that was miscellaneous is also an Antihepatitis C drug

A

Ribavirin

Also used for RSV in kids; Used with Pegylated Interferon Alfa 2a for Hep C

67
Q

what drug class is Sofosbuvir

A

Antihepatitis C Drug

Agent: Hep C Polymerase Inhibitor (AntiHCV)

68
Q

MOA of Sofosbuvir

A

Direct acting antiviral against Hep C virus;

prodrug that is converted to active form intracellularly & inhibits HCV NS5B RNA-dependent polymerase needed for viral replication and acts as a chain terminator.

69
Q

indications of Sofosbuvir

A

Chronic Hep C genotype 1, 2,
3, 4 (w/ Rabavirin or Peg Interferon α & Ribavirin)

(Also w/ Ledipasvir/Sofos buvir for Chronic Hep C genotype 1)

70
Q

what drug is in the class

Antihepatitis C Drug

HCV NS5A inhibitor/Hepatitis C
Polymerase Inhibitor

A

Ledipasvir & Sofosbuvir

71
Q

MOA Ledipasvir & Sofosbuvir

A

Ledipasvir inhibits HCV NS5A protein needed for viral replication;

Sofosbuvir inhibits NS5B RNAdependent RNA polymerase needed for viral replication and acts as a chain terminator

72
Q

Indications of Ledipasvir &

Sofosbuvir

A

Chronic Hepatitis C,

genotype 1

73
Q

what is the drug class of Rifampin

A

Antituberculus drug

Misc. Abx

74
Q

MOA of Rifampin

A

Inhibits bacterial RNA synthesis by blocking RNA transcription

75
Q

Indications of Rifampin

A

TB;

elimination meningococci from nasopharynx in carriers

76
Q

what is the drug class of Isoniazid

A

Antituberculus drug

77
Q

MOA of Isoniazid

A

Possibly interruption of mycolic acid synthesis resulting in disruption of bacterial cell wall

78
Q

Indications of Isoniazid

A

TB, latent TB

Module 7: Mali: ID (4 decks)

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