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Module 7: Mali: ID > ID Pharm Chart > Flashcards

ID Pharm Chart Flashcards

1
Q 
What drug is part of the class Antimalarial
4-aminoquinolone
A

Chloroquine

sulfate

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2
Q

MOA Chloroquine

sulfate

A

Increases
accumulation of
toxic free heme
in parasite

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3
Q

indications of Chloroquine

sulfate

A

P. vivax,
P. ovale,
P. malariae

sensitive P. falciparum
malaria

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4
Q

What drug class is Iodoquinol

A

Antiamebacide

halogenated hydroxyquinoline

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5
Q

MOA of Iodoquinol

A

unknown

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6
Q

indications of Iodoquinol

A

acute & chronic intestinal amebiasis

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7
Q

what is an Antiamebocide

Nitroimidazole antibiotic

A

Metronidazole

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8
Q

MOA of Metronidazole

A

disrupts helical DNA structure and causes DNA strand breakage

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9
Q

indications of Metronidazole

A

susceptible anaerobic bacterial & protozoal infxns;

C difficile infxns

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10
Q

what drug class is Mebendazole part of

A

Antihelminthic

Benzimidazole antihelmintic

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11
Q

MOA of Mebendazole

A

inhibits microtubule synthesis

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12
Q

indications of Mebendazole

A

Infxn of hookworm, pinworm, ascariasis trichuriasis

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13
Q

what drug is under the class Antihelminthic?

A

Praziquantel

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14
Q

MOA Praziquantel

A

causes spastic paralysis and tegumental damage in helminthes

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15
Q

Indications Praziquantel

A

schistosome, taenia infxn

several other rarer parasites

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16
Q

Drugs class of Permethrin

A

Antiscabide

Anti-pediculosis & anti-scabicide drug

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17
Q

MOA of Permethrin

A

delays Na ion influx through nerve and cell membrane producing paralysis and death

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18
Q

Indications of Permethrin

A

Tx head louse, scabies

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19
Q

drug class of Nitrofurantoin

A

Urinary antiseptic

Miscellaneous antibiotic

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20
Q

MOA of Nitrofurantoin

A

inhibits several bacterial enzyme

systems (including acetyl CoA) interfering with metabolism & possibly cell wall synthesis

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21
Q

Indications of Nitrofurantoin

A

Px/Tx
urinary tract
infections

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22
Q

Drug class of Acyclovir

A

Nucleoside

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23
Q

MOA of Acyclovir

A

Inhibits viral DNA
synthesis & viral
replication

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24
Q

indications of Acyclovir

A

Mucocutaneous Herpes Simplex (HSV-1 & HSV-2) infections,

VZV infections (varicella, shingles)

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25
what drugs are Nucleosides
Famcyclovir | Valcyclovir
26
MOA of Famcyclovir
Inhibits DNA polymerase, selectively inhibiting herpes viral DNA synthesis and replication
27
Indications of Nucleosides
``` HSV, Herpes Zoster (shingles) ```
28
MOA of Valcyclovir
Inhibits DNA polymerase; incorporates into viral DNA
29
what are the M2 pump inhibitors
1. Amantadine | 2. Rimantadine
30
MOA of Amantadine
Inhibits uncoating of influenza A virus preventing penetration of virus into host; dopamine agonists
31
indication of Amantadine
Influenza A, | Parkinson’s Disease
32
MOA of Rimantadine
Exact MOA unknown; possibly | inhibits viral uncoating and replication
33
indications of Rimantadine
Influenza A
34
what are the Neuroamidase inhibitors
Oseltamivir | Zanamivir
35
MOA of Oseltamivir
Prodrug converted to active form and inhibits cleaving of virus from cellular envelope preventing release
36
Indications fo Oseltamivir
Treatment & prophylaxis | influenza A & B
37
MOA of Zanamivir
Inhibits cleaving of virus from cellular envelope preventing release
38
indications of Zanamivir
Tx & Px influenza A & B
39
drug class of Ribavarin
Misc. | Also Anti- Hep C
40
MOA of Ribavarin
Inhibits replication DNA, RNA viruses via inhibition of protein synthesis
41
indications of Ribavarin
RSV in infants, Hepatitis C (with peg interferon alfa-2a)
42
Drug class of Lamivudine
Antiretroviral Drugs: | Nucleoside reverse transcriptase inhibitor (NRTIs)
43
MOA od Lamivudine
Inhibits viral RNA to DNA transcription
44
indications of Lamivudine
HBV, | HIV
45
Drug class of Delavirdine
Antiretroviral Drugs: Non-nuceloside Reverse Transcriptase inhibitors (NNRTI)
46
indications of Delavirdine
HIV
47
MOA of Delavirdine
Non-nucleoside reverse transcriptase inhibitor
48
what drug is under the class Antiretroviral Drugs: Protease inhibitors (PIs)
Darunavir
49
MOA of Darunavir
Binds to active site of | HIV protease
50
Indications of Darunavir
HIV
51
What drug is under the class Antiretroviral Drugs: Fusion Inhibitors
Enfuvirtide
52
what is the MOA of Enfuvirtide
Inhibits fusion of virus with host cell membrane; blocking entry and subsequent viral replication
53
Indications of Enfuvirtide
HIV
54
Drug class of Maraviroc
Antiretroviral Drugs: | CCR5 Antagonists
55
MOA of Maraviroc
Binds to human CCR5 receptors, | blocking HIV gp120 attachment and preventing cell entry
56
Indications of Maraviroc
HIV
57
Drug class of Raltegravir
Antiretroviral Drugs: | Integrase Inhibitors
58
MOA of Raltegravir
Inhibits HIV integras, preventing viral DNA insertion into host cell DNA
59
Indications of Raltegravir
HIV
60
what drug is ALSO in the class Antihepatitis B Drug ** HINT THIS IS A DRUG WE ALREADY SAW
Lamivudine
61
MOA of Lamivudine
Inhibits reverse transcriptase; incorporates into viral DNA (nucleoside reverse transcriptase inhibitor)
62
Inhibit Lamivudine
HBV/HIV
63
What drug is in the class Antihepatitis B or C Drug
Pegylated Interferon Alfa 2a
64
MOA of Pegylated Interferon Alfa 2a
``` 1. Binds to specific cell membrane receptors inhibiting viral penetration, translocation, transcription, protein processing, maturation and release 2. increases phagocytic activity macrophages 3. increases number and survival of cytotoxic T cells ```
65
Indications of Pegylated Interferon Alfa 2a
HBV, HCV infections
66
weird but what drug that was miscellaneous is also an Antihepatitis C drug
Ribavirin Also used for RSV in kids; Used with Pegylated Interferon Alfa 2a for Hep C
67
what drug class is Sofosbuvir
Antihepatitis C Drug | Agent: Hep C Polymerase Inhibitor (AntiHCV)
68
MOA of Sofosbuvir
Direct acting antiviral against Hep C virus; prodrug that is converted to active form intracellularly & inhibits HCV NS5B RNA-dependent polymerase needed for viral replication and acts as a chain terminator.
69
indications of Sofosbuvir
Chronic Hep C genotype 1, 2, 3, 4 (w/ Rabavirin or Peg Interferon α & Ribavirin) (Also w/ Ledipasvir/Sofos buvir for Chronic Hep C genotype 1)
70
what drug is in the class Antihepatitis C Drug HCV NS5A inhibitor/Hepatitis C Polymerase Inhibitor
Ledipasvir & Sofosbuvir
71
MOA Ledipasvir & Sofosbuvir
Ledipasvir inhibits HCV NS5A protein needed for viral replication; Sofosbuvir inhibits NS5B RNAdependent RNA polymerase needed for viral replication and acts as a chain terminator
72
Indications of Ledipasvir & | Sofosbuvir
Chronic Hepatitis C, | genotype 1
73
what is the drug class of Rifampin
Antituberculus drug Misc. Abx
74
MOA of Rifampin
Inhibits bacterial RNA synthesis by blocking RNA transcription
75
Indications of Rifampin
TB; | elimination meningococci from nasopharynx in carriers
76
what is the drug class of Isoniazid
Antituberculus drug
77
MOA of Isoniazid
Possibly interruption of mycolic acid synthesis resulting in disruption of bacterial cell wall
78
Indications of Isoniazid
TB, latent TB

Module 7: Mali: ID (4 decks)

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