ID Flashcards
Congenital CMV
- features
General
IUGR, prematurity
Skin
Petechiae, purpura, echymoses, jaundice
Hematopoietic Thrombocytopenia,anemia,splenomegaly
Hepatobiliary
Hyperbilirubinemia, elevated ALT, hepatomegaly
CNS
Microcephaly, seizures, periventricular calcifications
Eye
Chorioretinitis, strabismus, optic atrophy, microphthalmia
Ear
Sensorineural hearing loss
Congenital CMV
- who to tx
- how to tx
Neonates with “moderate to severe” symptomatic disease
During neonatal period
Valganciclovir for 6 months
Syphillis
early mainfestations
General
Prematurity, IUGR, FTT
Mucocutaneous
Snuffles, maculopapular rash followed by desquamation, blistering and crusting, condyloma lata
Reticuloendothelial Hepatosplenomegaly, lymphadenopathy
Hematologic
Coomb’s negative hemolytic anemia, thrombocytopenia
Skeletal
Pseudoparalysis, osteochondritis, diaphyseal periostitis, deminiralization/destruction of proximal
tibia metaphysis, osteitis
Neurologic
Aseptic meningitis, hydrocephalus, cranial nerve palsies
Ophthalmologic
Salt and pepper chorioretinitis, glaucoma, uveitis
When does a baby born to mom w syphilis not need workup/tx?
Appropriate treatment prior to or during pregnancy
Four-fold or greater fall in maternal RPR titer
Infant RPR non- reactive
OR
Infant RPR = mothers and asymptomatic
If baby needs workup for syphliis what does it include
• Physical exam
▫ Stigmata
▫ Ophthalmology,audiology
assessments
• CBC, (LFT’s)
• Lumbar puncture
▫ CSF WBC count
▫ CSF protein
▫ Treponemal & non- treponemal serologic tests
• Skeletal survey
• Syphilis serology
▫ Non-treponemal ▫ Treponemal
Tx for congenital syphilis
Intravenous crystalline penicillin G for 10 days
Congenital zika syndrome
CNS only
▫ Severe microcephaly with partially collapsed skull
▫ Thin cerebral cortices, subcortical calcifications
▫ Macular scarring, focal pigmentary retinal mottling
▫ Congenital contractures (arthrogryposis, club foot etc)
Toxoplasmosis - triad
hydrocephalus,
cerebral calcifications
chorioretinitis
Rubella - triad
cataracts, PDA, SNHL
Risk factors for early onset sepsis?
- Maternal intrapartum GBS colonization during current pregnancy
- GBS bacteriuria during current pregnancy
- Previous infant with invasive GBS disease
- Prolonged rupture of membranes (≥ 18 hours)
- Maternal fever (≥ 38.0oC)
Well baby with GBS+
what to do
No risk factors:
Adequate IAP: routine care
No IAP: observe 24-48 hrs (vital signs q3-4h), reassess & counsel pre-discharge
With risk factors:
at least observe 24-48 hrs (vital signs q3-4h)
consider CBC at 4h
Well baby with GBS- or unknown
what to do
No RF: Routine care
1 RF:
Adequate IAP: routine care
No IAP: observe 24-48 hrs (vital signs q3-4h), reassess & counsel pre-discharge
2 or more RF, or chorio:
at least observe 24-48 hrs (vital signs q3-4h)
consider CBC at 4h
Low risk criteria for febrile infant 1-3 mo
Previously healthy term infant
Non-toxic clinical appearance
No focal infection (except otitis media)
Peripheral leukocyte count 5.0 – 15.0 x109/L
Absolute band count £ 1.5 x109/L
Urine: £ 10 WBC per high field (x40)
Stool (if diarrhea): £ 5 WBC per high field (x40)
Bacterial pathogens for fever for:
0-28d
29-90d
3-36 m
0-28 d:
Most common: Group B streptococcus, E. coli
Less common: L. monocytogenes, S. aureus, group A streptococcus, K. pneumoniae
29-90 d:
Most common: Group B streptococcus, E. coli, S. pneumoniae
Less common: N. meningitidis, L. monocytogenes, S. aureus, group A streptococcus
3-36 mo:
Most common: S. pneumoniae
Less common: S. aureus, group A streptococcus, N. meningitidis
Empiric therapy for toxic infants (community aqcuired)
0-28d
29-90d
3-36 m
No/Yes = meningitis
Amp is for listeria
0-28 days
No Ampicillin + gentamicin or cefotaxime
Yes Ampicillin + cefotaxime
29-90 days
No Ceftriaxone + vancomycin ± ampicillin
Yes Cefotriaxone + vancomycin ± ampicillin
3-36 months
No Ceftriaxone + vancomycin
Yes Ceftriaxone + vancomycin
Mother with HSV
how to treat:
• First episode; born vaginally or by C/section after membrane rupture
• First episode; C/section prior to membrane rupture
• Recurrent episodes
• First episode; born vaginally or by C/section after membrane rupture
▫ Empiric acyclovir recommended
▫ If 24 hr swabs positive – full workup (incl LP and bcx for PCR) and start treatment
▫ If 24 hr swabs negative, complete 10 days of IV acyclovir
• First episode; C/section prior to membrane rupture
▫ Empiric acyclovir not recommended
▫ Swab at 24 hr swabs and observe
if positive – full workup and treatment
• Recurrent episodes
▫ Empiric acyclovir not recommended
▫ Swab at 24 hr and observe
if swabs positive – full workup and treatment
Septic arthritis pathogens abx when to switch how long
S aureus
Kingella kingae if <4 yo
▫ IV cefazolin
- Switch to oral when clinically improved, CRP decreased, compliance and follow-up assured
▫ If uncomplicated, antibiotic duration 3-4 weeks; 4-6 weeks for septic hip
Necrotizing fascitis
- bug
- mgmt
S.pyogenes
IV penicillin + clindamycin and surgery consult
Asplenic prophylaxis
- 0 – 5 years: amoxicillin 10 mg/k/dose bid
* > 5 years: Penicillin V 300 mg BID or amoxicillin 250 mg BID
Well young w chronically draining cervical node
Atypical mycobacterium
Lymph nodes
Acute bilateral
Respiratory viruses, enteroviruses, adenovirus, EBV, CMV
Acute unilateral
S. aureus, S. pyogenes (80%)
Subacute bilateral
HIV, EBV, CMV, toxoplasmosis
Subacute unilateral
Non-tuberculous mycobacteria,
M. tuberculosis, Bartonella henselae, tularemia, plague (Y. pestis)
Cat scratch disease
- bug
- presentaiton
- treatment
Bartonella hensalae
▫ Lymphadenitis (axillarymostcommon) ▫ Perinaud oculoglandular syndrome ▫ Hepatosplenic bartonellosis (granulomatous disease) ▫ Neuro-retinitis ▫ Encephalopathy ▫ FUO
▫ Azithromycin for lymphadenitis (shortens duration)
▫ Doxycycline + rifampin for neuroretinitis/CNS disease
Lyme disease
- bug
- presentation
- tx
• Borrelia burgdorferi
Erythema migrans Arthritis Bells palsy radiculoneuropathy (uncommon: meningitis, cardiac)
doxycycline
unilateral facial weakness, and vesicles in ear canal
Ramsay hunt
acyclovir and steroids
Acute flaccid myelitis
- eitiology
▫ Non-polio enteroviruses (EV D68, EV A71)
▫ Polioviruses (vaccine derived mainly)
▫ West Nile virus and some other arboviruses
Complications of varicella
Most likely after 12yo
most common - pneumonia
• General
▫ Pneumonia
▫ Hepatitis, pancreatitis, nephritis, orchitis
▫ Thrombocytopenia
• Bacterial infections
▫ Cellulitis, softtissue abscess, necrotizing fasciitis
• Neurologic ▫ Cerebellar ataxia ▫ Encephalitis ▫ Reye syndrome ▫ Stroke ▫ Zoster (including Ramsay Hunt syndrome)
mother with untreated gonorrhea
• Well appearing
▫ Conjunctival culture
▫ IM ceftriaxone 50 mg/kg (maximum 125 mg)
• Unwell
▫ Conjunctival, blood and CSF cultures
▫ Consult ID with established disease
C diff treatment
Mild (<4 abn stools/d)
Discontinue precipitating Abx; Follow-up
First episode; Mild/moderate; No change with Abx stoppage
PO metronidazole 10-14 days
First episode; Severe uncomplicated
PO vancomycin 10-14 days
First episode; Severe complicated
PO vancomycin 10-14 days
PLUS
IV metronidazole 10-14 days
First recurrence
Repeat as above
Second recurrence
Vancomycin in tapered or pulsed regimen
Fever in traveler
- emergency infections
▫ Malaria
▫ Typhoid fever
▫ Meningococcemia
▫ Viral hemorrhagic fevers
Positive TST
> /= 10 mm in no RF
> /= 5mm if RF
• HIV infection (well)
• Close contact with active contagious case (past 2 years)
• Presence of fibronodular disease on CXR (healed TB)
• Organ transplant
• TNF-α inhibitors
• Other immunosuppressive medications (e.g.
corticosteroids – equivalent of 315 mg/day for 31 month)
• End stage renal disease
TB tx
Isoniazid, Rifampin, Pyrazinamide, Ethambutol
• Latent TB infection
▫ INH for 9months or RIF for 4 months or INH+RIF for 3 months or INH + rifapentine x12 weekly observed doses
• TB disease
▫ Start with 4 drugs(INH,RIF,PYR,ETH)
▫ Step down to 3 drugs if fully sensitive strain
▫ Two months of 3-4 drugs, then INH+RIF to complete course (total duration depends on specifics of disease)
(4x2mo then 2X4mo)
• Consider DOT
• Pyridoxine in selected cases (malnutrition,
adolescents, pregnancy…)
• Vitamin D usually given for children with TB disease
how to prevent vertical transmission of HIV
• Antiretroviral therapy (zidovudine = AZT)
▫ Triple ART starting in 2nd trimester (or earlier)
▫ IV zidovudine during labor
▫ Zidovudine to infant for 6 weeks
- Elective Cesarean section if VL >1000 copies/mL
- Avoidance of breast feeding
Hep B + mom - what to do w newborn
HBIG and HB vaccine within 12 hours of birth
HB vaccine at 1 and 6 months
Check tires at 9-12 mo
Who to give VZIG to post exposure
Basically those who can’t get varicella vaccine
Give acyclovir if lesions too
1) Immunocomp children w/o hx of varicella or varicella immunization
2) Susceptible pregnant women
3) Newborn infant whose mother had ONSET of chicken pox within 5 days before delivery or within 48 hours of delivery
4) Hospitalized premature infant (>/= 28 wga) whose mother lacks a reliable history of chicken pox or serologic evidence of protection against varicella
5) Hospitalized premature infant (< 28 weeks gestation or birth weight < 1000 gram) regardless of maternal history of varicella or varicella-zoster virus serostatus
Hep A
post exposure
Hep A vaccine within 2 weeks of exposure
If less than 6mo or C/I to vaccine, Ig should be given
Give vaccine + Ig to immunocomp
What are airborne precautions
Varicella, zoster Measles Tuberculosis Smallpox
5 moments of Hand hygiene
- Before touching a patient
- Before clean/aseptic procedures
- After body fluid exposure/risk
- After touching a patient
- After touching patient surroundings
AOM bugs
Streptococcus pneumoniae (25% to 40%) ▫ Non-typeable Haemophilus influenzae (10% to 30%) ▫ Moraxella catarrhalis (5% to 15%)
Skin infections
- bugs
- tx
S. aureus, Group A streptococcus
Impetigo: PO: Cloxacillin, Cephalexin
Cellulitis: IV: Cloxacillin, Cefazolin
PO: Cloxacillin, Cephalexin
Necrotizing Fasciitis: IV: Cloxacillin (or Cefazolin or penicillin) + clindamycin ± vancomycin
Human bites - what to do about Hep B
If unknown status - vaccinate that child
If one of the children has HepB, give HBIG & vaccine to the other child if they are non immune or incompletely immunized
Contraindications to breastfeeding`
HIV HTLA HSV if active lesions on breast TB if contagious Mastoiditis (pump and dump on that breast, BF from other)
West Nile Virus
presentation
Asymptomatic 80%
Fever 20%
Neurologic disease <1%
aseptic meningitis, encephalitis, acute flaccid paralysis