ID Flashcards

1
Q

disease NP will see Neuro, derm, Resps, immune

which one needs referral? 2

A

NEURO
Meningitis (C)

DERM
Lyme Disease (D)
Pityriasis Rosea (D)

RESP
Croup (D)
Influenza (D)
Epiglotittis (C)

IMMUNE
Infectious mono in adults (D)

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2
Q

8 ID in kids

A
Coxsackie (D)
Fifth’s Disease (D)
Roseola (D)
Mumps (D)
Measles Rubeola (D)
Rubella (D)
Varicella (D)
Infectious mono (D)
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3
Q

what conditions will have rash

A

Meningitis
MMR
Varicella
Mono - with pen

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4
Q

Meningitis

A

Inflammatory disease of membranes (meninges) surrounding the brain and spinal cord

Defined by elevated WBCs in the CSF

Neurological sequelae are common among survivors

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5
Q

Community acquired Meningitis bacterial 2

other 2?

most cause?

fungal?

A

Bacterial
Streptococcus pneumoniae - has vaccine
Neisseria meningitidis - has vaccine

Haemophilus influenzae (haemophilus).
Listeria monocytogenes (listeria).
These bacteria can be found in soft cheeses, hot dogs and luncheon meats. 

most cases are caused by a viral infection - usually mild and often clears on its own.

Cryptococcal meningitis is a common fungal form of the disease that affects people with immune deficiencies, such as AIDS

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6
Q

s/s of meningitis - Triad

A

non-blanching petechial or purpuric rash, stiff neck

acute febrile illness with rapid onset

intense headache, fever, nausea, vomiting, photophobia

Classic TRIAD
1 Fever

2 Nuchal rigidity (neck stiffness – the inability to flex the head forward due to rigidity of the neck muscles)

3 Change in mental status (increasing intracranial pressure can cause confusion)

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7
Q

if sepsis what happens?

A

if sepsis - Meningococcemia - circulatory collapse, haemorrhagic skin rash and a high fatality rate.

has long term sequelae which include hearing loss, neurologic disabilities, and digit or limb amputations.

Meningococcus organism releases a toxin which activates the clotting factor, can cause DIC - variety of small clots form in the vessels. These clots use up all the platelets and then there is bleeding throughout the body.

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8
Q

Meningitis Bacterial Dx

A

Bacterial – Diagnosis

Nuchal rigidity
+ Kernig flex knee and pull straigh
+ Brudzinski - bend head, knees automatically goes up
CSF – increased opening pressure
Leukocytosis, increased protein, decreased glucose
Blood Cultures

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9
Q

meningitis Vaccines? 4

A

Hib
Pneumococcal (Prevnar 13)
Meningococcal C (Neisvac-C) and B (Bexsero)
Menactra and Menveo (quadrivalent conjugate) – A, C, Y, W-135

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10
Q

S/E of lyme disease :
first stage
2nd
late signs - months - years

A

Erythema Migrans - bull eyes rash - spirochete Borrelia burgdorferi bacteria

2nd: 
Bell’s palsy (temporary paralysis of one side of the face, CN7) - usually self limiting
arthralgia, joint to joint pain
Headache,  myalgia, fatigue, pruritis
Cardiac involvement
late: 
Chronic arthritis-large joints affected
Neurological complaints
Memory loss
Atrophic skin
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11
Q

test for lyme disease
treatment

CDC criteria for Lyme Disease

A

Serological testing IgG and IgM antibodies to B. burgdorferi

cdc : Presence of EM OR
At least one late manifestation plus laboratory confirmation of infection.
Joint swelling, Bell’s palsy, AV block
Tests: ELISA and Western Blot

Treatment:

Doxycycline (adults)
100mg po BID x 14-21 days
Amoxicillin
Cefuroxime
Supportive
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12
Q
Pityriasis Rosea
looks like? 2
followed by?
tx?
other tx?
A

heralds patch, xmas tree pattern
follows a viral infection
self limiting - clear in 4-6 weeks - supportive measures
Pruritis – topical corticosteroid or antihistamines
Severe itching–po acyclovir x 1 week (may reduce symptoms by 1-2 weeks)

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13
Q

2 Etiology of croup

whos at risk?

tx

A

Parainfluenza virus
Respiratory syncytial virus RSV

Children 3 months – 5 years
Peak at 18-24 months

Supportive treatment
Usually mild, lasting less than 1 week
Cool night air exposure or air humidifier (even though there is no evidence of benefit for this practice)
Stay calm.Comfort or distract your child — cuddle, read a book or play a quiet game. Crying makes breathing more difficult.
Acetaminophen for fever
Warm fluids – loosen secretions
No smoking in child’s home

Dexamethasone (0.15 – 0.6 mg/kg) – single dose - Max dose 10 mg

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14
Q

Epiglottitis definition and etiology

s/s?

what to do?

A

Rapid inflammation of the epiglottis which results in edema and airflow obstruction.

Etiology
H. Influenza type B

s/s
toxic appearance
Drooling
High fever
Muffled voice
Severe sore throat

ER

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15
Q

mono virus?

SS Triad

dx?

tx? precaution?

A

Epstein-Barr virus

SS-TRIAD
1 Fever
2 Tonsillar pharyngitis
3 Lymphadenopathy (posterior cervical)
Malaise, Fatigue, Headache
Splenomegaly (50% of patients)
 rash with PEN
dx
Lymphocytosis – 40-50%
Throat culture to detect strep
Mono spot test - bw for antibodies
May see elevated LFTs
tx
Symptomatic – rest, fluids, Tyl
Corticosteroids (Prednisone) for tonsillar obstruction
Acyclovir not recommended
If + strep, do NOT use Amoxicillin
Avoid saliva contact
No contact sports X 1 month

precaution - no contact sports to prevent rupture of spleen

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16
Q

etiology for each condition

Hand foot mouth disease

Fifth’s Disease

Roseola

Mumps (D)
Measles Rubeola (D)
Rubella (D)

Chickenpox (D)
Infectious mono (D)
A

HFM - Coxsackie virus

Fifth’s Disease - parvovirus b19

Roseola - herpes 6

Mumps - mumps - supportive tx
Measles - morbillivirus
Rubella - RNA virus

chicken pox - Varicella - need shringrix to prevent herpes zoster
Infectious mono - Epstein-Barr

17
Q

HFM disease - virus?

seen in what age

ss

tx

A

Coxsackievirus A16

Highest in children under 10

ss - fever
Oral lesions – 5-10 vesicles on hard palate, tongue, mucosa-PAIN
Skin lesions – 2-8 mm. vesicles on palms, soles, skin

Symptomatic tx
Vesicles heal without scarring
Usually resolves in 2-3 days

18
Q

5th disease - virus, aka?

when most contagious

ss

tx

A

Parvovirus B19 aka “slapped cheek”

Most contagious before onset of rash - laced rash

Prodromal -3-7 day fever, headache, cough, 20% without symptoms
Rash in 3 stages
Slapped cheek 1-4 days
Lacy maculopapular starts on trunk
Rash subsides 

Supportive tx

19
Q

Roseola - signature s/s

tx

A

High fever x 3-5 days, abruptly resolves

Lymphadenopathy, red TMs, irritability
Then, onset of macular rash begins on trunk and spreads to face, neck extremities
Non-pruritic lesions disappear 1-2 days

tx
Supportive
Acetaminophen for fever
Fluids to prevent dehydration
Teach parents that the high fever
   does not mean serious disease
Most cases, benign and self-limiting
20
Q

Measles

4 c’s

dx

A

Respiratory infection caused by the morbillivirus - airborne

Complications include: sepsis, pneumonia, encephalitis, and death

Conjunctivitis
Coryza (rhinitis)
Cough
Koplik spots - in mouth and body

dx - bw for antibodies

21
Q

mmr vaccine

A

Adults born between 1970 and 1996 should ensure that they have received two doses of MMR vaccine.

22
Q

hep a how contract

how many vaccine

how long protection?

A

fecal oral route

2 doses, 0. then 6-12 months

up to 25 in adults 14-20 in kids

23
Q

hep b how contract

how many vaccines

how long proctection

twinrex

A

blood, fluids

3 doses, 0, 1, 6

hep a n b - Schedule: 0, 1, 6 months

24
Q

typhoid risk

cause?

route?

vaccine

caution with abx?

A

risk up 6-30x in asian countries

An acute, life-threatening febrile illness caused by the bacterium Salmonella enterica serotype Typhi.

Fecal-oral transmission route

Both typhoid vaccines protect 50%–80% of recipients;
Travelers should be reminded that typhoid immunization is not 100% effective, and typhoid fever could still occur.

Vivotif (oral, live attenuated) >6yrs - good for 5 yrs

Typhim Vi (injectable, inactivated) >2 yrs - good for 2 years

Vaccination with Vivotif should be delayed for >72 hours after the administration of any antibacterial agent

25
Q

meningitis risk

vaccine

how long good for?

A

Travelling in the African meningitis belt during the epidemic season

vaccine - Quadrivalent meningococcal conjugate vaccine (Menactra)

good for 5 years

26
Q

TD bugs

tx

at risk for?

non rx tx to prevent

A

Enterotoxigenic E. coli, Campilobacter jejuni, Shigella spp, Salmonella spp.

cipro has more resistance, now use Azithromycin

when get TD, at risk for IBS in future

to prevent - Non-antimicrobial options for prophylaxis
BSS (Bismuth subsalicylate)
Probiotics
Dukoral

27
Q

infection through mosquito - 5

use what to prevent -

A

1 yellow fever virus - live vaccine, lifelong protection,
if get it avoid aspirin or NSAIDs, which may increase the risk for bleeding

Because of the risk of serious adverse events that can occur after yellow fever vaccination, clinicians should only vaccinate people who:

1) are at risk of exposure to YFV or 
2) require proof of vaccination to enter a country. 

2 malaria
3 zika
4 Japanese Encehpalitis - vaccine 0, 28d, up 3 yrs
5 Dengue Fever

1 Permethrin on clothes

2 on skin - Picaridin 20% - PiActive – up to 12 hours protection
Oil of lemon eucalyptus