ICU pain and delirium Flashcards

1
Q

what are the 3 quality of evidence ratings for guideline recommendations

A
A = High
B = moderate
C = observational study only (weak)
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2
Q

what percent of patients remember pain more than any other event in the ICU

A

82%

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3
Q

untreated pain can lead to what

A

chronic pain
PTSD
lower health related quality of life

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4
Q

what are 4 ways pain is assessed in ICU

A
  1. cisual analogue scale
  2. numeric rating scale
  3. subjective measures
  4. objective measures
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5
Q

what are the objective measures for pain

A
  1. heart rate
  2. bp
  3. respiratory rate
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6
Q

what are the subjective measures for pain

A
  1. facial grimacing
  2. sweating
  3. head movements
  4. posturing
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7
Q

opdiods stimulate what receptors

A

mu, kappa and delta receptors (produce both analgesia and sedation)

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8
Q

what are the most commonly used drugs for pain in the ICU

A
  1. fentanyl
  2. morphine
  3. hydromorphone
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9
Q

what is usually used for pain in renally impaired patients

A

morphine (metabolized hepatically)

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10
Q

what is an opioid adverse reaction especially pertinent with morphine

A

hypotension

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11
Q

what are the characteristics of an ideal sedative

A
  1. rapid onset
  2. easy titration
  3. lack of accumulation
  4. no active metabolites
  5. rapid awakening
  6. inexpensive
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12
Q

what are the consequences of negletincg anxiety

A
  1. ventilator dyssynchrony
  2. agitation
  3. increased O2 consumption
  4. removal of lines or catheters
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13
Q

what are the goals of sedation

A
  1. analgesia
  2. anxiety
  3. amnesia
  4. paralysis
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14
Q

what is the MOA of benzodiazepines

A

enhances inhibitory effect of GABA receptors

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15
Q

what beneficial effects do Benzo’s have to patients in the ICU? what effect do they not have?

A

potent anxiolytic and amnestic effects

No analgesic effects

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16
Q

Which benzo does not have an active metabolite; best for patients with hepatic dysfunction

A

lorazepam

17
Q

what benzo is used for acutely agitated patients

A

midazolam

18
Q

how is midazolam metabolized

A

hepatically (CYP3A4)

19
Q

what are the goals of analgesia and sedation

A

improve patient comfort , decrease stress responses

20
Q

what benzo has the largest volume of distribution

A

midazolam

21
Q

what caution goes with midazolam?

A

accumulation concerns with hepatic and renal failure or with prolonged use

22
Q

what are the two common used for lorazepam

A
  1. long term sedation (greater than 48 hours

2. alcohol withdrawal

23
Q

what precaution is unique with lorazepam

A

diluent toxicity - caused by propylene glycol vehicle

24
Q

what are some common effects of diluent toxicity

A
  1. renal failure
  2. hyperosmolality
  3. lactic acidosis
25
Q

what are some risk factors for diluent toxicity

A
  1. high dose Ativan
  2. prolonged Ativan infusion
  3. renal or hepatic dysfunction