IBS IBD GVHD Sigmoid Diverticular Disease Flashcards
How do endoscopinc and microscopic evaluations look with IBS?
Normal
Who is IBS more common in?
Females between 20-40 in high income countries
In a person with intestinal inflammation what events contribute to increased bacterial exposure?
- disruption of mucus layer
- dysregulation of epithelial thight junctions
- increasesd intestinal permeability
- Increased bacterial adherence to epi cells
In a person with IBD, what cytokines are produced at a higher amount?
- TNF a
- IL-1B
- IL-6
- IL-12
- IL-23
Where is UC at predominately compared to Crohn’s disease?
- Crohn:
- Ileum
- Colon
- Rectum is spared in ~40%
- Ulcerative Colitis:
- Colon only
Which disorder in IBD includes skip lesions?
- Crohns disease
- UC is diffuse
What disease under IBD is limited to the mucosa>
Ulcerative Colitis is limited to the mucosa while Crohn Disease is transmural
What disease under IBD has deep knife like ulcers?
- Chron disease
- UC has superficial broad based ulcers
What disease under IBD has marked fibrosis ,serositis, granulomas, and fistulas?
- Crohn’s disease
- UC has NO granulomas or fistulas and mild to none fibrosis and serositis
What disease under IBD has a risk of toxic mega colon?
UC
What is the earliest lesion of crohn disease?
- Apthous ulcer that may progress to elongated serpentine ulcers along axis of bowel proximal to distal
- Ulceration can be so deep it leads to fissures which lead to a fistula
What part of the colon does UC always involve?
Rectum
Where is UC limited to?
- Mucosa
- The areas of ulceration lead to a psuedopolyp formation
Histopatholoogy of UC?
- Crypt abscess
- Psuedopyloric metaplasia
- Disease limited to mucosa
Extra intestinal manifestations in UC?
Primary sclerosis cholangitis
