IBS IBD GVHD Sigmoid Diverticular Disease Flashcards
How do endoscopinc and microscopic evaluations look with IBS?
Normal
Who is IBS more common in?
Females between 20-40 in high income countries
In a person with intestinal inflammation what events contribute to increased bacterial exposure?
- disruption of mucus layer
- dysregulation of epithelial thight junctions
- increasesd intestinal permeability
- Increased bacterial adherence to epi cells
In a person with IBD, what cytokines are produced at a higher amount?
- TNF a
- IL-1B
- IL-6
- IL-12
- IL-23
Where is UC at predominately compared to Crohn’s disease?
- Crohn:
- Ileum
- Colon
- Rectum is spared in ~40%
- Ulcerative Colitis:
- Colon only
Which disorder in IBD includes skip lesions?
- Crohns disease
- UC is diffuse
What disease under IBD is limited to the mucosa>
Ulcerative Colitis is limited to the mucosa while Crohn Disease is transmural
What disease under IBD has deep knife like ulcers?
- Chron disease
- UC has superficial broad based ulcers
What disease under IBD has marked fibrosis ,serositis, granulomas, and fistulas?
- Crohn’s disease
- UC has NO granulomas or fistulas and mild to none fibrosis and serositis
What disease under IBD has a risk of toxic mega colon?
UC
What is the earliest lesion of crohn disease?
- Apthous ulcer that may progress to elongated serpentine ulcers along axis of bowel proximal to distal
- Ulceration can be so deep it leads to fissures which lead to a fistula
What part of the colon does UC always involve?
Rectum
Where is UC limited to?
- Mucosa
- The areas of ulceration lead to a psuedopolyp formation
Histopatholoogy of UC?
- Crypt abscess
- Psuedopyloric metaplasia
- Disease limited to mucosa
Extra intestinal manifestations in UC?
Primary sclerosis cholangitis
Extra intestinal manifestations of IBD?
- Stomatitis and apthous ulcers
- Steatosis
- Gall stones
- Joint issues
- Erythema nodosum
- KIdney issues
Neoplasia in IBD related to?
Duration and extent of disease as well as neutrophilic response
Precursor lesions in IBD?
- Dysplasia associated lesion mass
Collangenous colitis?
watery diarrhea without weight los in middle aged women
Lymphocytic colitis?
Watery diarrhea without weight loss in setting of celiac disease and autoimmune
What is diverticular disease?
Due to acquired psuedodiverticular outpouching of colonic mucosa and submucosa.
Sx of diverticular disesase?
- intermittent cramping
- Continuous lower abd discomfort
- constipation
- distension
- feel like never empty rectum
What category of IBD has fat/vitamin absorption issues as well as recurrence after surgery?
Crohn’s Disease
What disease has an association with toxic megacolon?
UC
