IBS/IBD

Question 1

Most common IBS symptoms?

Answer 1

Abdominal discomfort
Constipation
Diarrhea

Question 2

Tx of moderate IBS-C

Answer 2

polyethylene glycol

Question 3

Tx of persistent IBS-C

Answer 3

Cl channel activator

guanylyl cyclase agonist

Question 4

Tx moderate IBS-D

Answer 4

Loperamide

bile acid sequestrants

Question 5

Tx persistent IBS-D

Answer 5

5-HT 3 antagonist

Antibiotics

Question 6

MOA Lubiprostone

Answer 6

Stimulates secretion of Cl-rich fluid into intestine

Question 7

MOA Linaclotide

Answer 7

Indirect stimulation of Cl channel by guanylyl cyclase activation in intestinal epithelium
Increases cGMP, activates CFT
Results in Cl-rich secretion and bowel movement acceleration

Question 8

Major health risk of alosetron, 5- HT 3 antagonist?

Answer 8

Ischemic colitis

Severe constipation

Question 9

Anti-TNF therapy and risks

Answer 9

prevents TNF from biding receptors

Increased infection risk

Question 10

Anti-Integrin therapy and risks

Answer 10

affects trafficking of circulating lymphocytes across vessel walls in GI tissue/CNS
PML!!