Hepatic Clearance Flashcards
1
Q
3 determinants of hepatic drug clearance
A
Hepatic blood flow
Free drug
Intrinsic clearance
2
Q
Pre systemic clearance
A
“first pass”
[Drug] reduced prior to reaching liver by GI CYP 3A4
3
Q
Systemic clearance
A
Direct integration of drug into circulation
4
Q
High extraction ratio
A
high hepatic clearance
“nonrestricted”
dep only on blood flow, not plasma protein binding or hepatic enzymatic metabolism
5
Q
Low extraction ratio
A
Low hepatic clearance
“restricted”
Blood flow less important
pp binding important
6
Q
Lidocaine with CHF
A
Vd reduced, so reduced lidocaine clearance due to poor perfusion
