IBD meds

Question 1

infliximab- monoclonal antibody

Answer 1

immunomodulator, GI anti inflammatory
Used for crohns, Ulcerative colitis.
MOA: used to treat IBD by blocking effects of tumor necrosis factor to decrease inflm.
Preg category C

Question 2

prednisone

Answer 2

Anti inflamatory, antiasthma. and corticosteroid.
MOA: suppresses inflm and abnormal immune response. Suppresses adrenal fx in chronic doses.
Preg category B

Question 3

sulfasalazine

Answer 3

GI anti-inflammatories
Used to treat mild to moderate Ulcerative colitis and as an adjunct therapy to it. Off label to tx crohns.
MOA: locally acting anti inflm action of the colon.
AE: anaphylaxis. do not admin to patients with allergies to sulfa drugs, salicylates, or furosemide. chemically similar to asprin