IBD + Celiac's disease

Question 1

Macroscopic findings at endoscopy for Crohns disease include?

Answer 1

Mucosal inflammation
Aphthous ulcers
Fissures
Cobblestoning 
Strictures

Question 2

Macroscopic findings at endoscopy for UC?

Answer 2

Friable mucosa and ulcers
Limited to colonic + rectal mucosa
Crypt abscesses, no granulomas

Question 3

Which HLA groups are associated with Celiac’s disease?

Answer 3

HLA-DQ2/8

Question 4

What serological test would you do if you suspect Celiac’s disease?

Answer 4

IgA TTG (tissue transglutaminase)

Question 5

What does silent Celiac disease refer to?

Answer 5

Seropositivity + characteristic biopsy findings but asymptomatic

Question 6

What does latent Celiac disease refer to?

Answer 6

Seropositivity but no histological changes

Question 7

Which is more common, Crohn’s or UC?

Answer 7

Crohns twice as common

Question 8

What should be checked before commencing thiopurines?

Answer 8

TPMT (enzyme required for metabolism of thiopurines)

Question 9

Name two examples of thiopurines?

Answer 9

Azathioprine

6-mercaptopurine (6-MP)

Question 10

Which HLA group is more prevalent in patients with Chrohns disease?

Answer 10

HLA B27

Question 11

What are the two dermatologic presentations of Crohns disease?

Answer 11

Erythema nodosum (10-15%)
Pyoderma grangrenosum (1%)