Iatrogenesis Flashcards
Definition of Iatrogenesis
Harm caused by medicine or a physician
- Deleterious effects of therapy or diagnostic procedures independent of the condition they were used for
- Can have devastating psychomotor and social consequences
If ranked, Iatrogenesis would rank ____ in the leading cause of death
6th!
Adverse Drug Reaction (ADR)
Noxious response to drugs used in usual doses
Adverse Drug events (ADEs)
Any injury that occurs from a drug
- usually dose-related
- Noxious response
- Drug administration error
- Any other circumstance that leads to an injury
Prevalence of ADRs and ADEs
- 3-7% of all hospital admissions
- 88% preventable
- 100,000 emergency visits from ADEs
- 5-10% of hospital costs
How ADE’s happen in…. nursing homes
- Inappropriate ordering
- Inadequate monitoring
How ADE’s happen… in the community
Patient errors
Any new symptom in the elderly is _________ until excluded
Drug-related
Risk factors for PDE’s
- Polypharmacy
- Multimorbidity
- No safety profile studies
- Multiple physicians
- Altered drug metabolism
- Cognitive impairment
- Functional deficits and disabilities
- Hospitalization for medical or surgical procedures
What percentage of people 57-85 have at least one prescription?
- 81%
On average, how many medications are nursing home residents on?
7-8, with 33% having 9 or more
How many people on medicare have 5 or more medications?
50%
What does polypharmacy and mutimorbidity increase the risk of?
- ADRs
- Drug-drug interactions
- Hip fractures
- “prescribing cascades”
- Non-adherence to medications
What is a prescribing cascade?
- Drug-related symptoms misinterpreted as new illness
- so then that provider adds another medication….
Tools to improve prescribing practices
- Beers criteria
- START/STOPP criteria
- FORTA list
- Medication appropriateness index (MAI)
- ACOVE project
- GerontoNet ADR risk score
- Comprehensive geriatric assessment