IAP

Question 1

2 reasons to carry out IAP

Answer 1

1) To determine speech and language organization

2) If mesial temporal resection is planned, is there risk of global amnesia after surgery?

Question 2

Only selected patients undergo procedure: language

Answer 2

• Patient is left-handed or not naturally right-handed

* Any other hints that has right hem. speech representation, e.g., lesion in left language areas but fluent speech

Question 3

Only selected patients undergo procedure: memory

Answer 3

• Impairments on verbal AND nonverbal learning and memory in tests in clinic
• Evidence of bitemporal abnormality on EEG and/or MRI
• Conflict in lateralization by EEG vs MRI or EEG/MRI and Neuropsyc tests

Question 4

eSAM Language Test

Answer 4

• Comprehension
• Reading single words
• Object naming
• Serial speech (e.g., name the days of the week)
• Spelling
• Repetition
• these tests are administered in practice beforehand (as a control). Anything that the patient could not do is not tested during infusion.

Question 5

eSAM Memory Test

Answer 5

• 8 objects presented before injection
• During injection show 8 more objects to awake hemisphere.
–> have to make sure patient attends to these objects. “What colour is it?” “How do you use it?”
• After drug has warn off: 24 objects for a yes-no recognition test (i.e. include 8 distractor items as well)