Functional neuroanatomy Flashcards

1
Q

Frontal lobe

A
  • Motor cortex: motor control
  • Primary motor cortex M1 (Area 4)
  • Premotor cortex (Area 6): motor output of speech
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2
Q

Prefrontal cortex

A

• Language: Speech production: Area 44, 45 in the Inferior frontal gyrus (IFG)
• Epoptic processing (monitoring: keep information ‘online’) In the middle frontal gyrus (MFG)
• Executive functions:
- Temporal organization of goal-directed actions
- Attention, planning, organisation, decision making, reasoning and emotional processing, impulse control

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3
Q

orbitofrontal cortex

A

→Strongly connected to the amygdala by the Uncinate fasciculus
→Regulate emotions

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4
Q

Insula

A
  • Hidden within the sylvian fissure
  • Somatic-visceral sensations (Penfield stimulation)

Neuroimaging:
• Sensory-motor control (more posterior):
–> Visceral sensations
–> Autonomic control (heart rate, blood pressure)

  • Introception: the sense of the physiological condition of the body
  • Olfactory and gustatory regions
  • Socio-emotional, ex: empathy

• Cognitive:

  • -> Attention
  • -> Speech production: motor planing (more anterior)
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5
Q

Parietal lobe

A

• Somatosensory cortex: area 3 (basic sensory information), area 1
(vibration/texture) and area 2 (size/shape of objects)
• Spatial functions
• Language (left): Reading and writing, phonological and semantics
• Dorsal stream of vision (where)
• Multisensory integration: infromation from the senses

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6
Q

Temporal lobe

A
-Auditory processing
• Primary auditory (BA 41, 42)
• Secondary auditory area (22)
-Wernicke’s area: posterior temporal
• Speech comprehension
-Ventral stream of vision (what)
-Hippocampus
     →Memory
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7
Q

Limbic cortex

A

Involved in behavioral and emotional response, survival
• Cingulate cortex
• Parahippocampal gyrus / Hippocampus
• Amygdala: emotions, response to stress
But also:
• The thalamus, sends output to the cingulate
• Hypothalamus (production of important hormones and regulation of thirst, hunger, mood, etc)
• and basal ganglia (reward processing, habit formation, movement and learning) are also involved in the actions of the limbic system.

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8
Q

Occipital lobe

A

• Primary visual area (V1: BA 17)
- Within the banks of the calcarine fissure
• Secondary visual area (V2: BA 18)
• Associative visual areas (V3, V4, V5 (MT))
• Processing of visual information

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9
Q

Brain tumors

A

• Cancerous growth inside the brain
• two types: glioma & meningioma
▪ Can still affect or destroy the neurons in the region where the tumor grows
▪ Can also destroy axons
▪ Can push the brain into the skull or away
▪ Depending on the type of tumor (I, II, III IV), more or less usefull to study… If growing very fast (III, IV), new problems every day, hard to study

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10
Q

Glioma

A
tumor from the glial cells: Most tumors
• Different types of glial cells
• Microglia
• Oligodendrocytes
• Astrocytes
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11
Q

Meningioma

A
tumor from the meninges
• Dura mater
• Arachnoid
• Pia mater
→ tumor that grows between the skull an the brain
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12
Q

Anterior cerebral artery (ACA)

A

Supplies the upper part and the medial surface

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13
Q

Middle cerebral artery

A
  • along the Sylvian fissure
  • a lot of branches
  • supplies the lateral surface: frontal, parietal, temporal (part)
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14
Q

Posterior cerebral artery (PCA)

A

Supplies the occipital areas and part of the temporal lobe

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15
Q

Stroke

A

interruption of blood supply in an area of the brain

2 types: ischemic & hemorrhagic

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16
Q

Ischemic Stroke

A
  • obstruction by a blood clot

* the blood flow is cut-off in that brain area (local)

17
Q

Hemorrhagic Stroke

A
  • Sometimes a defect in membrane thickness of a blood vessel
  • Causes aneurysm
  • Can burst: bleeding inside the brain
18
Q

Traumatic Brain Injury (TBI)

A

-Sudden damage to the brain caused by a violent blow or jolt to the head
Can be:
Open or closed
Focal: penetrating wound, open fracture, laceration, hematoma, contusion…
Or
Diffuse: Concussion, axonal lesions

19
Q

Diffuse axonal injury

A
  • one type of diffuse brain damage
    -Other types: hypoxic brain damage, brain swelling,
    vascular injury
    -Usually no intracranial haematoma
    -Previously described as shearing injury
    -Can happen when the head is rapidly accelerated, ex: car accident, shaken baby syndrome
    -Often causes unconsciousness and vegetative state
20
Q

Disconnection Syndromes

A

Injuries to white matter
Closed head trauma (CHT) can affect white
matter by:
- shear and stretch forces that distort the axons
- vascular disruption and edema
Case of CHT: deep contusions causing damaged
fibers in the corpus callosum
Can be due to:
-Congenital Agenesis of the corpus callosum
-Callosotomy

21
Q

Epilepsy

A

Abnormal discharge in a part of the brain and extends to other parts
1) Partial seizures (focal seizures)
- Neuronal discharge in one area of the brain
- 2 types
▪ Simple partial seizures
- focal abnormalities, local symptoms in
somatosensory, vision, audition, olfaction…
▪Complex partial seizures
- frequently: symptoms of disruptions of higher
mental functions
2) Unilateral seizures
- Discharge spread over wide area in one hemisphere
- Clinical phenomenon: contralatera

22
Q

Epilepsy treatment

A

-Medication: antiepileptic
-When medication doesn’t work there is another
option: Surgery
Find the foyer first
-Electroencephalogram (EEG) to find where there is abnormal electrical activity
-Neuropsychological testing
• Memory (verbal memory, memory for faces)
• Language
• Executive functions (ex: Wisconsin test)
-You know exactly what brain area you removed

23
Q

Brain Surgery

A

• Importance of localisation and sulci
• Penfield and the Montreal Procedure: to localise functions and know what to remove and what not to remove to try to preserve functions
→ Under local anaesthesia, you can ask the patient to
speak while you stimulate different brain areas
→ Ex: stimulate a region: stop speaking = temporary
lesion
• Modern presurgical mapping: fMRI to localise brain functions in each individual
- sometimes the brain can be distorted by a lesion or a
tumor
- functional reorganisation
• Animal studies: can remove exactly the cortex you want to study without touching the axons underneath or adjacent brain area

24
Q

birth of neuropsychology

A

• Pierre Paul Broca
• Patient called Tan
- Had a stroke
- Unable to speak
→ the only thing he could say: ‘‘ Tan ’’
- Autopsy: found very localised damage in the Left frontal lobe
-called the area ‘‘Broca’s area’’
- First proof that when you damage a specific brain area = specific deficit
- Functional localization

25
Q

PET

A
  • Inject radioactive substance in blood that emits positively charged particules (positrons)
  • Measure variations in blood flow (by detecting the positrons) associated with cerebral functions
26
Q

EEG (ElectroEncephaloGraphy)

A
  • Electrodes on the skull
  • Detects variation in electrical potential emitted but groups of neurons
  • Very good temporal resolution, but not spatial
27
Q

MEG (MagnetoEncephaloGraphy)

A
  • Measures magnetic field
  • Better spatial resolution
  • Very good temporal resolution
28
Q

Seed-based Resting State

A
  • Use a specific Region of Interest (ROI) as a seed:
  • See what other brain areas are connected (correlated activity) with the seed
  • Group difference, effect of learning etc…