I. Meninges Flashcards
What are the layers of the dura?
2 Layers
External periosteal layer and inner meningeal layer
What are the layers of the dura?
2 Layers
External periosteal layer and inner meningeal layer
Which layer of dura extends beyond foramen magnum?
Inner meningeal layer extends beyond FM and forms spinal dura
Where does the dura end in the spine?
S2
What is the arachnoid made of?
Fibroblasts, collagen fibers and some elastic fibers
With tight junctions
What are the layers of the pia?
Intimal layer (avascular, nutrients from CSF) Epipial layer (continuous with arachnoid trabeculae)
What is the dentate ligament?
Formed by pia
Stretches from midpoint between dorsal and ventral roots on lateral spinal cord surface and attach to arachnoid/dura
What is the filum terminale?
Extension of epipia and continues from S2 and ends as the coccygeal ligament
Virchow-Robin spaces
Perivascular potential space between blood vessels and surrounding sheath of leptomeninges entering nervous tissue
Blood supply to the meninges
Anterior meningeal: ophthalmic
Middle meningeal: maxillary
Posterior meningeal: occipita/vertebral
Blood supply to the tentorium
Cavernous ICA
SCA
Proximal PCA
Neural innervation to supratentorial dura
Anterior fossa: V1
Middle fossa: V2
Posterior fossa, mastoid air cells: V3
Neural innervation to infratentorial dura
Upper cervical roots (C2, C3)
Cranial nerve X
Neural innervation to spinal dura
Recurrent branches of spine
Embryologic origin of meninges
Ectoderm: leptomeninges, ependyma, neural parenchyma, glia
Mesoderm: dura, blood vessels
Function of CSF
Nutrient, waste, cushion, neurotransmitters, para/endocrine
Levels of these ions in CSF vs Plasma:
Na, K+, Cl-, Ca2+, uric acid, glucose
Na same
Higher Cl-
Lower K+, Ca2+, uric acid, glucose
Normal glucose level in CSF
45-80 mg/dL (2/3 of serum)
Normal protein in CSF
What level is used to assess CSF leak?
Beta-transferrin
Froin’s syndrome
CSF with high protein but normal cell count
Advanced spinal tumor/meningitis blocking CSF flow
CSF Specific Gravity
1.007
CSF pH
7.33-7.35
Traumatic CSF tap ratio of RBC to WBC
700 RBCs to 1 WBC
Site of CSF production
70% choroid plexus
18% ultrafiltrate
12% metabolic H2O production
Increases or decreases CSF production: carbonic anhydrase inhibitor
Decreases
Increases or decreases CSF production: Norepinephrine
Decreases
Increases or decreases CSF production: Volatile anesthetics
Increases
Increases or decreases CSF production: CO2
Increases
Total volume of CSF in a 70kg man
150 mL total