Brain Barriers Flashcards
1
Q
What is the BBB formed by?
A
Capillary endothelial tight junctions
Pinocytic activity in endothelial cells
Astrocyte foot processes
2
Q
3 types of molecular movements through the BBB
A
Diffusion
Carrier-mediated
Active transport
3
Q
What are highly permeable to BBB?
A
Highly permeable: H2O, CO2, O2, lipid-soluble (EtOH, barb, heroin, anesthetics)
4
Q
What are slightly permeable to BBB?
A
Ions (Na+, Cl-, and K+)
5
Q
What are impermeable to BBB?
A
Plasma proteins, protein-bound molecules, large organic molecules
6
Q
What are circumventricular organs?
A
Midline ventricular systems of specialized tissues with absent BBB due to fenestrated capillaries
7
Q
Name the circumventricular organs (7)?
A
Lamina terminalis Neurohypophsysis Median eminence of hypothalamus Subfornical organ Subcommissural organ Pineal gland Area postrema
