Hypothyroidism Flashcards
1
Q
Recall the causes of primary and secondary hypothyroidism
A
Primary = AI = myxoedema Secondary = dysfuction of adenohypophysial signalling so cannot produce sufficient TSH
2
Q
Recall the clinical features of hypothyroidism
A
Deepening voice Increased central adiposity Depression Striae, weak skin Diabetes Bradycardia Cold intolerance Fatigue
3
Q
What is the drug of choice to treat hypothyroidism?
A
Levothyroxine sodium
4
Q
How does monitoring differ between patients with primary and secondary hypothyroidism?
A
Primary: Use TSH as guide
Secondary: T4 in circulation (TSH not elevated)
5
Q
What is the first-line of treatment in myxoedema coma?
A
IV T3
6
Q
Recall 4 side-effects of thyroid-hormone over-replacement
A
- Osteoperosis
- Tachycardia
- AF
- Tremor due to increased beta-adrenergic sensitivity
7
Q
What might compete with thyroid hormone for TBG binding sites?
A
Co-administered drugs such as phenytoin and salicylates
8
Q
What complications are associated with T3 medication (rather than T4)?
A
Palpitations
Tremor
Anxiety
