Hypothyroidism Flashcards
1
Q
What is hypoT?
A
- most common clinical thyroid disorder in US
- deficient thyroid hormone production
2
Q
What causes primary hypoT?
A
- autoimmune disorder
- loss of thyroid tissue
- iodine deficiency, anti-thyroid drugs
3
Q
What causes secondary hypoT?
A
-pituitary insult
4
Q
What causes tertiary hypoT?
A
- anorexia
- hypothalamic tumors
5
Q
What are the symptoms of hypoT?
A
- fatigue
- cold intolerance, dry/cool extremities
- facial puffiness, periorbital swelling
- bradycardia
- constipation
- forgetful, paresthesias, delayed DTRs
- menorrhagia, anemia, irregular menses
- goiter is still possible!
6
Q
Subacute Thyroiditis
A
- inflammation of thyroid gland following viral infection
- hyperT –> euT –> hypoT
- 2-4 months of sxs
- tx not always necessary
7
Q
Postpartum Thyroiditis
A
- within 3-6 months of delivery
- thyroxine binding globulin increases in pregnancy and with OCP use then drops
- > 50% remain hypoT
8
Q
Silent Thyroiditis
A
- not associated w/ pregnancy or delivery
- similar course as subacute (2-4 months)
- but clinically like Hashimoto’s
- spontaneous resolution expected
9
Q
What is another name for Hashimoto’s thyroiditis?
A
chronic lymphocytic thyroiditis
10
Q
Hashimoto’s
A
- most common adult cause of hypoT
- firm goiter from chronic TSH stimulation
- myxedema possible
- autoimmune disorder
- genetic predisposition
11
Q
Post-therapeutic/Iatrogenic Thyroiditis
A
- radioactive iodine induce: hypoT can occur early or late depending on dosage
- subtotal thyroidectomy: highest risk in first year
12
Q
Goiter
A
- most pts with non-Hashimoto goiter are euthyroid or hyperT
- goitrous hypoT in endemic area: due to iodine deficiency, basically eliminated with iodized salt
13
Q
What is the most common form of congenital hypoT?
A
- cretinism
- found in severely deficient areas
- major cause of mental retardation
14
Q
Euthyroid Sick
A
- clinical syndrome found in acutely ill patients
- commonly decreased total and unbound T3, normal T4, and TSH
- can also see elevated T3 and/or T4 initially
15
Q
Myxedema Coma
A
-life-threatening complication of hypoT
