Hypothyroidism

Question 1

What are the Primary causes of Hypothyroidism ?

Answer 1

1. AI hypothyroidism
2. Iatrogenic
3. Drugs
4. Congenital hypothyroidism
5. Iodine deficiency
6. Infiltrative disorders
7. Overexpression of type 3 deoiodinase n infantile hemangioma

Question 2

Transient Hypothyroidism

Answer 2

• silent thyroiditis, including postpartum thyroiditis
• subacute thyroiditis
• withdrawal of thyroxine treatment in individuals with an intact thyroid after 131I treatment or subtotal thyroidectomy for Graves’ disease

Question 3

Secondary Hypothyroidism

Answer 3

• Hypopituitarism
• isolated TSH deficiency or inactivity
• hypothalamic disease: tumors, trauma, infiltrative disordes, idiopathic

Question 4

Classifications of AI Hypothyroidism

Answer 4

1. May be associated with a goiter: Hashimoto or Goitrous Thyroiditis
2. Atrophic thyroiditis
3. Subclinical hypothyroidism

Question 5

Prevalence of AI Hypothyroidism in women and men

Answer 5

Women: 4 per 1000
Men: 1 per 1000

Question 6

AI hypothyroidism is associated with what?

Answer 6

1. Chronic exposure to a high-iodine diet
2. Genetic Factors

Question 7

Mean age at diagnosis of AI Hypothyroidism

Answer 7

About 60 years, prevalence of overt hypothyroidism increases with age