Hyponatremia Due To Inappropriate Antidiuresis

Question 1

Ectopic production of AVP by Lung cancer or other neoplasm results from what

Answer 1

It results abnormal expression of the AVP-NPII gene by primary or metastatic cancers

Question 2

4 distinct forms of Osmoregulation

Answer 2

1. Reset osmostat- one of the most common
2. Inappropriate antidiuresis without a demonstrable defect in the osmoregulation of plasma AVP
   3.
   4.

Question 3

Clinical characteristic of Acute Hyponatremia

Answer 3

S/Sx of water intoxication -
Mild HA
Confusion
Anorexia
N/V
Coma
Convulsions
Severe cases may be lethal

Question 4

Gradually developing Hyponatremia presentation

Answer 4

May be largely ASYMPTOMATIC

Question 5

EUVOLEMIC HYPONATREMIA

Answer 5

Increase in body water with little or no change in body sodium
- defect in osmotic suppression of AVP due to
1. Nonhemodynamic stimulus: Nausea, cortisol deficiency
2. Primary defect in osmoregulatin caused by another disorder (eg malignancy, stroke or pneumonia) - SIADH
- other cause: AVP-independent activation of renal V2 receptors also called NEPHROGENIC inappropriate antidiuresis (NSIAD)O