hypothalmus Flashcards
what is the hypothalus involoved in
The hypothalamus is involved in those functions that require the integration of somatic, autonomic and endocrine mechanisms with motivated behavioral
expression.
Feeding
fight
flight
reproduction
what is the hypothalmius autonomiccaly linked to
◼ reticular formation (especially autonomic
centers)
◼ limbic system ( memory/emotion)
◼ pituitary gland ( endocrine system)
what are the boundaries of the hypothalmus
◼ Caudal: mammillary body
◼ dorsal/superior: hypothalamic sulcus
◼ Rostral: lamina terminalis
◼ Inferior: optic chiasm, pituitary stalk
◼ Lateral: internal capsule
what are the divisions of the hypothalmus
◼ Supraoptic (anterior) hypothalamus ( optic chiasm)
◼ Tuberal (middle) hypothalamus
◼ Mammillary (posterior)
hypothalamus
what are the hypothalmic efferents
◼ Medial forebrain bundle (MFB)
◼ Dorsal longitudinal fasciculus (DLF)
◼ Hypothalamo-hypophyseal tract
middle forebrain bundle
- what does it project to
- disorgaized bundle not a typical tract
- goes to the reticular formation
dorsal longitudinal fasciculus (DLF)
What nervous system does it control
- hypothalmus to the dorsal nucleus to the vagus
- controls PNS
hypathalmo-hypohyseal tract
- synthesize proteins/hormones that are realeased into blood vessesls
- connection to the pituitary
from other nuclei in the hypothalmus - nuerosecretory neurons that end on bloodvessles/ secrete a hormine into them which then goes to the anterior pituitary to stimulate its homrones
afferents to the hypothalmus
◼ Reticular formation (via MFB)
◼ Limbic pathways
◼ Fornix
◼Amygdalar pathways
◼ Monoaminergic pathways
functions of the anteriro hypothalamus
◼ Thermoregulation
◼ Water balance
◼ Circadian rhythms
◼ Maternal behavior
◼ Sleep
Anterior hypothalamus : thermo regulation
- responses
◼ Somatic (shivering)
◼ Autonomic (sweating, vasomotion)
◼ Behavior ( turning on heat and air conditioner)
- thermoreceptive neurons ( screen blood temp)
mechanism of fever
normal > 98.6
fever >103
- not a loss of function but a setpoint that is raised to a higher temp
what are sweat glands innervatred by
cholinergic sympathetics
mechanism of fever
- how do NSAIDS affect this
- antipiretic drugs and NSAIDS they nock out COX and reduce body temp
water balance
- what happens when you lose water when its hot
- endocrine relesases ADH ( vasopressin)
- tells kidney to conserve water
- causes you to become thirsty and drink water
what nucleus is circadian rythm generated by
- what does it recieve and from where
- what happens if there are leasions to the SCM
◼ Generated by suprachiasmatic
nucleus (SCN)
◼ SCN receives collaterals from optic
tract (retino-hypothalamic fibers)
◼ Lesions of SCN disrupt 24-hour
temperature, sleep, and endocrine
cycles
where is the superchiasmatic nucleus
- above the optic chiasm
functions of the tuberal hypothalmus
◼ Control of plasma hormone levels
◼ Feeding behavior
◼ Sexual behavior
◼ Aggressive behavior
what are feedinf behaviors based on and what happens if there are lesions to these
◼ Concept of feeding center (LH) and
satiety center (VMH)
◼ Lesions of LH ( lateral hypothalmuc) induce anorexia
◼ Lesions of VMH (ventral medial hyopthalmus) induce obesity
what are the important nuclei of feeding behavior
◼ Arcuate nucleus
◼ Paraventricular nucleus
sensing metabolic state: feeding hormones
◼ Ghrelin- appetite promoting (GI tract)
◼ Insulin (pancreas)
◼ Leptin (adipose tissue)
what is feeding behavior conrolled by
◼ Behavior
◼ Autonomic (salivary secretion,
gastric secretion)
◼ Metabolic need
what is attack behavior evoked by
◼ Attack behavior evoked by
stimulation of lateral hypothalamus
what us defensive behvaior ekoked by
Defense behavior evoked by
stimulation of ventral medial
hypothalamus
what is flight behvior ekoked by
◼ Flight behavior evoked by
stimulation of dorsal hypothalamus
sexual behavior
◼ VMN has estrogen receptors
◼ VMN important in female sexual
behavior
◼ Sexually dimorphic nucleus in POA
Hypothalamic lesion
what are the signs and symptoms of the this hypothalmic lesions: anteriro pituitary dysfunction
- Gonadal dysfunction
- Thyroid
- Cortisol
- Growth hormone
symptoms of posterior pituitary dysfunction
- Diabetes insipidus
symptoms of hypthalmic dysfunction
- Polyphagia or starvation
- Impaired temperature regulation
- Impaired autonomic function
symptoms of horners syndrome
miosis
ptosis
anydrosis