Hypothalamic/pituitary drugs Flashcards
1
Q
What are two medical indications for use of growth hormone?
A
- Growth hormone deficiency
- Turners syndrome
2
Q
List five indications for the use of octreotide
A
- Carcinoid tumor
- Acromegaly
- Gastrinoma
- Glucagonoma
- Esophageal varices
3
Q
Can desmopressin be used in the treatment of nephrogenic diabetes insipidus?
A
No; desmopressin is an antidiuretic hormone analog that requires renal response and thus is effective only in pituitary diabetes insipidus
4
Q
A patient has hyponatremia with low serum osmolarity and high urine osmolarity; name a drug that works by antagonizing the defective pathway
A
This is syndrome of inappropriate antidiuretic hormone secretion and can be treated by demeclocycline, which is an antidiuretic hormone antagonist
5
Q
Examples of ADH antagonists
A
- Conivaptan
- Tolvaptan
- Demeclocycline
6
Q
Block action of ADH at V2–receptor
A
- Conivaptan
- Tolvaptan
Memory aid:
- _V_2 receptor antagonist
- _V_aptans
7
Q
Uses of desmopressin acetate
A
- Central (not nephrogenic) DI
- von Willebrand disease
- Sleep enuresis
