ADH agonists Flashcards
1
Q
Examples
A
- Antidiuretic hormone
- Desmopressin
- Vasopressin
2
Q
Can desmopressin be used in the treatment of nephrogenic diabetes insipidus?
A
No; desmopressin is an antidiuretic hormone analog that requires renal response and thus is effective only in pituitary diabetes insipidus
3
Q
Uses of desmopressin acetate
A
- Central (not nephrogenic) DI
- von Willebrand disease
- Sleep enuresis
4
Q
Desmopressin is selective for what receptor?
A
V2
5
Q
Desmopressin MOA in DI
A
Activate insertion of aquaporin water channels in collecting tubule
6
Q
Aside from DI, what are other uses of desmopressin and its mechanism for such use
A
- Mild hemophilia A or von Willebrand disease
- Increases the factor VIII and vWF activity
- Esophageal varices, colon diverticula
- Constricts vascular smooth muscles via V1