ADH agonists Flashcards

1
Q

Examples

A
  • Antidiuretic hormone
  • Desmopressin
  • Vasopressin
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2
Q

Can desmopressin be used in the treatment of nephrogenic diabetes insipidus?

A

No; desmopressin is an antidiuretic hormone analog that requires renal response and thus is effective only in pituitary diabetes insipidus

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3
Q

Uses of desmopressin acetate

A
  • Central (not nephrogenic) DI
  • von Willebrand disease
  • Sleep enuresis
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4
Q

Desmopressin is selective for what receptor?

A

V2

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5
Q

Desmopressin MOA in DI

A

Activate insertion of aquaporin water channels in collecting tubule

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6
Q

Aside from DI, what are other uses of desmopressin and its mechanism for such use

A
  • Mild hemophilia A or von Willebrand disease
    • Increases the factor VIII and vWF activity
  • Esophageal varices, colon diverticula
    • Constricts vascular smooth muscles via V1
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