Hypothalamic Glucose Sensing

Question 1

Where is glucose sense?

Answer 1

Brain
Liver
Pancreas
Adipocytes
Muscle

Question 2

True or false:
The brain can store energy

Answer 2

False - the brain can’t store energy so needs a continuous supply

Question 3

What happens if we make the brain think its going to be hypoglycaemic but maintain a euglycaemic periphery?

Answer 3

Countterregulatory hormones are increased

Question 4

What happens if we maintain euglucaemia in the brain but have hypoglycaemic periphery?

Answer 4

Counterregulatory hormones are decreased

Question 5

Name some characteristics that the medial amygdalar nucleus and the ventromedial nucleus share

Answer 5

Body weight control
Ovulaiton
Sexual behaviour
Fear/anxiety behaviours

Question 6

What are the key glucose sensing regions of the brain?

Answer 6

Ventral medial hypothalamus and medial amygdala

Question 7

What things able use to test glucose sensing ability in the lab?

Answer 7

Transgenic mouse models, retrograde labelling and targeted microinjections

Question 8

What are the two main GABA receptors?

Answer 8

GABA A and Gaba B

Question 9

GABA A is ionotropic/metabotropic

Answer 9

Ionotropic

Question 10

GABA B is iontropic/metabotropic

Answer 10

Metabotropic

Question 11

True or false:
There are a number of areas in the hindbrain that have GABAergic input

Answer 11

False
There are a number of areas in the forebrain that have GABAergic input but not as many in the hindbrain

Question 12

Where do GABAergic neurons in the medial amygdala nucleus project to?

Answer 12

The ventral medial hypothalamus