Hypothalamic Control of Water Homeostasis Flashcards
mechanism of ADH action
where is anti-diuretic hormone (ADH)/Vasopressin produced?
anti-diuretic hormone (vasopressin) is produced in the cell bodies of the paraventricular and supraoptic nucleotides of the hypothalamus
where is ADH/vasopressin stored?
it is stored in the posterior pituitary gland until it is released
where is oxytocin produced
in the cell bodies of the paraventricular and supraoptic nuclei
where is oxytocin stored
in the posterior pituitary gland until it is released
What in the hypothalamus senses a change in solute concentration/osmolality
increased solute concentration is sensed by osmoreceptors in the hypothalamus
once osmoreceptors in the hypothalamus sense an increase in solute concentration, what happens?
once the increase is sensed, the osmoreceptors signal the PVN and SON to produce ADH
What is blood/plasma osmolality measuring?
measure of [solute] in the plasma
solute includes things such as NA, CL, K, urea, glucose
what is the range of normal blood osmolality?
280-303 mOs/kg
describe what ADH is secreted in response to and why
ADH is secreted in response to increased blood osmolality to increase water reabsorption and return to the blood
describe the brattelboro rats (no ADH)
- result of a naturally occurring mutation that was later bred for experimentation
- kidneys cant retain water
- excessive thirst
- lots of pee
what is diabetes insipidus
increases risk of seizures secondary to dehydration
describe ADH circadian pattern
ADH secretion increases during sleep to increase water reabsorption and decrease nocturnal urine production
