Hypopituitarism

Question 1

What is the order of hromone loss in panhypopituitarism

Answer 1

GH –> LF –> FSH –> ACTH –> TSH

Question 2

Causes of pan hypopituitarism.

Answer 2

• Tumors
  
  • pituitary adenoma
  • craniopharyngioma - Rathke pouch embryonic remnant tumor, seen in children.
  • other CNS tumors
  • Granulomatous diseases
• Irradiation
• Trauma -
  
  • skull fractures
  • birth trauma
  • Surgery
• Sheehan syndrome
• Autoimmune hypophysitis
• Tumors or disorders of the hypothalamus
• Congenital agenesis, exceptionally rare.
• Congenital birth trauma or ischemia
• Congenital Kalman syndrome, no gonadotrophs
• Prader Willi syndrome, lack GH

Question 3

Go to the pathology cards and do all those