Hypertrophic cardiomyopathy Flashcards
What is hypertrophic cardiomyopathy
Leads to thick, heavy and stiff myocardium
How does it occur
New sacromeres in parallel
What does it cause
Left ventricular hypertrophy that is asymmetrical
How does it affect stroke volume
Decreases it
What are the signs (pulse and auscultation)
Crescendo-decrescendo murmur (aortic stenosis), bifid pulse (two pulses) and an S4 heart sound
It is the most common cause of death in young athletes. True or false
True
Other symptoms of HCM
Dyspnoea and syncope
What is the cause?
Autosomal dominant that causes a missence mutation
What is a missence mutation
When one base is changed for another and causes a change in that amino acid
What does it show on histology
Myocyte disarray
What is the treatment
Beta blockers, Ca2+ channel blockers and possibly surgery
What drug do you not give
Digoxin
