Hypertriglyceridemia Flashcards
if patient has ASCVD or severe hypercholesterolemia (LDL over 190), how do you manage their statin?
high intensity statin
patients with diabetes should be put onto what statin therapy?
moderate to high statin
if primary prevention ASCVD score over 7.%, how do you manage their statin?
moderate intensity statin
in adults with DM and ASCVD score over 20%, it may be reasonable to add ______
ezetimibe
define persistent hypertriglyceridemia
fasting triglycerides over 150 despite lifestyle intervention and statin therapy
what diseases increase risk of hypertriglyceridemia?
uncontrolled diabetes and CKD
what diet/lifestyle factors increase risk of hypertriglyceridemia?
alcohol
high fat/sugar
sedentary lifestyle
which metabolic disorders increase risk of hypertriglyceridemia?
obesity
metabolic syndrome
insulin resistance
what is the greatest intervention to reduce triglycerides?
weight loss/diet modifications (70%)
which drug has the greatest reduction to triglycerides?
2nd best?
fibrates
niacin and 2-4g of omega-3
adults with severe hypertriglyceridemia (over 500) who require prevention of acute pancreatitis, _______ therapy is reasonable
fibrate and omega-3
___________ is the only triglyceride risk-based nonstatin approved for ASCVD risk reduction
icosapent ethyl
what are other causes of muscle symptoms not related to medication intervention?
vitamin D deficiency
high or new levels of physical activity
hypothyroidism
how can we evaluate if it is statin-caused myalgia?
symmetric and specific to one area in large muscles
occurs 4-12 wks after initiation
improves within 2 wks of holding statin
a patient is only considered statin intolerant if?
they’ve tried at least 2 other statins
